Evidence map›Paper›PMID 34453103›Full record

ArticleJournal of human hypertension2022

Sympathetic-transduction in untreated hypertension.

Matthew D Kobetic, Amy E Burchell, Laura E K Ratcliffe, Sandra Neumann, Zoe H Adams, Regina Nolan, Angus K Nightingale, Julian F R Paton, Emma C Hart

Abstract read
In one paragraph

Article in Journal of human hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Resting sympathetic transduction in veterans with PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Autonomic effects of simulated periodic breathing in patients with chronic heart failure on contemporary guideline-directed therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  4. Hypoxia disrupts neurovascular regulation of blood pressure in normotensive and untreated hypertensive men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  5. Acetate concentration correlates with MSNA in patients with resistant hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Sympathetic vascular transduction and baroreflex sensitivity in the context of severe COPD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
  10. Article
  11. Article
  12. Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Review
  13. Comparison of signal-averaging and regression approaches to analyzing sympathetic transduction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
  14. Article
  15. Advances in pathogenesis and treatment of essential hypertension.Frontiers in cardiovascular medicine · 2022
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Matthew D KobeticSchool of Physiology, Pharmacology, and Neuroscience, Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-2313-4864
Amy E BurchellCardionomics Research Group, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, UK.
Laura E K RatcliffeDepartment of Nephrology, Lister Hospital, East and North Hertfordshire NHS Trust, Hertfordshire, UK.
Sandra NeumannSchool of Physiology, Pharmacology, and Neuroscience, Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7306-9047
Zoe H AdamsSchool of Physiology, Pharmacology, and Neuroscience, Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.
Regina NolanCardionomics Research Group, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, UK.
Angus K NightingaleSchool of Physiology, Pharmacology, and Neuroscience, Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0001-9435-726X
Julian F R PatonSchool of Physiology, Pharmacology, and Neuroscience, Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.
Emma C HartSchool of Physiology, Pharmacology, and Neuroscience, Clinical Research and Imaging Centre, University of Bristol, Bristol, UK. Emma.hart@bristol.ac.uk.ORCID http://orcid.org/0000-0002-4534-9586

Funding

British Heart Foundation FS/11/1/28400British Heart Foundation FS/17/38/32935
6 · The paper itself

Abstract

Transduction of muscle sympathetic nerve activity (MSNA) into vascular tone varies with age and sex. Older normotensive men have reduced sympathetic transduction so that a given level of MSNA causes less arteriole vasoconstriction. Whether sympathetic transduction is altered in hypertension (HTN) is not known. We investigated whether sympathetic transduction is impaired in untreated hypertensive men compared to normotensive controls. Eight untreated hypertensive men and 10 normotensive men (age 50 ± 15 years vs. 45 ± 12 years (mean ± SD); p = 0.19, body mass index (BMI) 24.7 ± 2.7 kg/m

Indexed as

HypertensionSympathetic Nervous SystemAdultAgedBlood PressureBody Mass IndexHeart RateHumansMaleMiddle AgedMuscle, Skeletal

Identifiers

PMID34453103
PMCPMC8766277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.