ArticleScientific reports2021
Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Optimization of Ultrasound-Assisted Extraction of Thymbra Spicata L. Using Response Surface Methodology: Polyphenol Profile and Antibacterial Activity.Chemistry & biodiversity · 2026Article
- Ethnopharmacological and Antiaging Evaluation of Salvia cadmica: Modulation of MMP1/MMP3 and Collagen in Oxidative Stress-Induced Senescence.Chemistry & biodiversity · 2026Article
- Ultrasound-assisted aqueous extract of Campanula macrostachya enhances fibroblast repair via antioxidant and cytokine-modulatory mechanisms.Protoplasma · 2026Article
- Onosma armenum Extract Loaded Mesoporous Silica Nanoparticles for the Prevention of Biofilm-Associated Infections.ChemistryOpen · 2026Article
- Comparative Ultrasonic Bath and Probe Extraction of Piperine fromBiomolecules · 2025Article
- Article
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6 authors.
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Abstract
Cosmos caudatus (C. caudatus) is a medicinal plant that is high in bioactive compounds such as phenolics. In this study, an ultrasound extraction method was used to optimise the extraction of bioactive compounds from C. caudatus leaves. Response surface methodology (RSM) based on a Box-Behnken design (BBD) was applied to obtain the optimum extraction parameters which is solid-liquid ratio (10-30 g/mL), particle size (180-850 µm) and extraction time (20-30 min) for maximal quercitrin and total phenolic content (TPC) yields. Analysis of antimicrobial activity was performed against two human pathogenic microbes: Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) by the agar well diffusion method. The optimal ultrasonic extraction condition was as follow: solvent-liquid ratio of 1:28 (g/mL), particle size of 485 µm, and duration of 30 min, respectively. Remarkably, extraction using ultrasonic method had recovered more bioactive content and antioxidant activity than the Soxhlet method. The extract also exhibited good antimicrobial activities. Due to the above findings, the ultrasonic extraction was found to be suitable to improve recovery extraction of quercitrin and TPC from C. caudatus leaves. It also opens the possibility that the plant extract can be used for functional food and antimicrobial agents in various applications.
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