ArticleNature communications2021
Stable representation of a naturalistic movie emerges from episodic activity with gain variability.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Realignment of representational drift in mouse visual cortex via flexible electrode arrays.Nature biomedical engineering · 2026Article
- Article
- Single-Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stability through plasticity: Finding robust memories through representational drift.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Temporal coding carries more stable cortical visual representations than firing rate over time.Nature communications · 2025Article
- Homeostasis of a representational map in the neocortex.Nature neuroscience · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
- High-dimensional cortical signals reveal rich bimodal and working memory-like representations among S1 neuron populations.Communications biology · 2024Article
- Differential stability of task variable representations in retrosplenial cortex.Nature communications · 2024Article
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- Article
- Representations in human primary visual cortex drift over time.Nature communications · 2023Article
- Learning low-dimensional generalizable natural features from retina using a U-net.Advances in neural information processing systems · 2022Article
- The geometry of representational drift in natural and artificial neural networks.PLoS computational biology · 2022Article
- Drifting neuronal representations: Bug or feature?Biological cybernetics · 2022Review
- Article
- Review
- Stimulus-dependent representational drift in primary visual cortex.Nature communications · 2021Article
- An implanted lennula approach to measure neural CaImaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Visual cortical responses are known to be highly variable across trials within an experimental session. However, the long-term stability of visual cortical responses is poorly understood. Here using chronic imaging of V1 in mice we show that neural responses to repeated natural movie clips are unstable across weeks. Individual neuronal responses consist of sparse episodic activity which are stable in time but unstable in gain across weeks. Further, we find that the individual episode, instead of neuron, serves as the basic unit of the week-to-week fluctuation. To investigate how population activity encodes the stimulus, we extract a stable one-dimensional representation of the time in the natural movie, using an unsupervised method. Most week-to-week fluctuation is perpendicular to the stimulus encoding direction, thus leaving the stimulus representation largely unaffected. We propose that precise episodic activity with coordinated gain changes are keys to maintain a stable stimulus representation in V1.
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