Evidence map›Paper›PMID 34452996›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

METTL14 facilitates global genome repair and suppresses skin tumorigenesis.

Zizhao Yang, Seungwon Yang, Yan-Hong Cui, Jiangbo Wei, Palak Shah, Gayoung Park, Xiaolong Cui, Chuan He, Yu-Ying He

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. [Role of m6A methylation modification in photoaging and ultraviolet-induced skin cancers].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  6. Article
  7. Article
  8. The crosstalk of mTrends in biochemical sciences · 2025
    Review
  9. YTHDFs as radiotherapy checkpoints in tumor immunity.The Journal of experimental medicine · 2025
    Review
  10. Article
  11. Article
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  13. Article
  14. NZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.Journal of experimental & clinical cancer research : CR · 2024
    Article
  20. RNAs mHeliyon · 2024
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zizhao YangDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.
Seungwon YangDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8970-7373
Yan-Hong CuiDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-4169-6521
Jiangbo WeiDepartment of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.ORCID 0000-0003-2691-6490
Palak ShahDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.
Gayoung ParkDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.
Xiaolong CuiDepartment of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-1345-2271
Chuan HeDepartment of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.
Yu-Ying HeDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637; yyhe@medicine.bsd.uchicago.edu.
University of Chicago · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
YTHDF2 and UVB damage response in skin cancerR01ES024373 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2015 to 2023
$4.3M
The mechanistic role of METTL14 in UVB-induced skin tumorigenesisR01ES030576 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2019 to 2023
$3.0M
Direct Oxidative Nucleic Acids DemethylationR01ES030546 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2019 to 2023
$1.9M
FTO and RNA methylation in arsenic tumorigenicityR01ES031534 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2020 to 2022
$1.2M
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR000430NCI NIH HHS P30 CA014599NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES024373NIEHS NIH HHS R01 ES030546NIEHS NIH HHS R01 ES030576NIEHS NIH HHS R01 ES031534
6 · The paper itself

Abstract

Global genome repair (GGR), a subpathway of nucleotide excision repair, corrects bulky helix-distorting DNA lesions across the whole genome and is essential for preventing mutagenesis and skin cancer. Here, we show that METTL14 (methyltransferase-like 14), a critical component of the N

Indexed as

AnimalsAutophagyCarcinogenesisCell Line, TumorDNA-Binding ProteinsDNA DamageDNA RepairFemaleGenes, Tumor SuppressorHumansIntracellular Signaling Peptides and ProteinsMaleMembrane GlycoproteinsMethylationMethyltransferasesMiceDdb2 protein, mouseDNA-Binding ProteinsGpm6a protein, mouseIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMethyltransferasesMettl14 protein, mouseNbr1 protein, mouseNerve Tissue ProteinsRNA-Binding ProteinsRNA, MessengerYthdf1 protein, mousem6A RNA methylationMETTL14nucleotide excision repairultraviolet radiationUVB

Identifiers

PMID34452996
PMCPMC8536359
OpenAlexW3194680510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.