ArticleProceedings of the National Academy of Sciences of the United States of America2021
Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- A prefrontal cortex-hypothalamus circuit for heart rate control in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Anterior Cingulate Cortex Projections to the Amygdala in Primates: Topographic and Layer-Specific Organization Underlying Emotion and Mood Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.Nature communications · 2026Article
- Modulating the Interplay Between Impulsivity and Interoception Through HD-tDCS to the Right Insula and Anterior Cingulate Cortex.Biomedicines · 2026Article
- The encoding of interoceptive-based predictions by the paraventricular nucleus of the thalamus D2R+ neurons.iScience · 2026Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.bioRxiv : the preprint server for biology · 2025Article
- Manipulation of interoceptive signaling biases decision making in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Integrating the dual-system theory in motor: dynamic framework construction for motor decision-making.Frontiers in psychology · 2025Article
- Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables.Schizophrenia bulletin · 2024Article
- Interoceptive Signals Bias Decision Making in Rhesus Macaques.bioRxiv : the preprint server for biology · 2024Article
- Heartfelt choices: The influence of cardiac phase on free-choice actions.Psychophysiology · 2024Article
- Eye tracking is more sensitive than skin conductance response in detecting mild environmental stimuli.PNAS nexus · 2024Article
- Evolutionarily conserved neural responses to affective touch in monkeys transcend consciousness and change with age.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Timing along the cardiac cycle modulates neural signals of reward-based learning.Nature communications · 2024Article
- The role of interoception in reducing trauma-associated distress: a feasibility study.European journal of psychotraumatology · 2024Article
- Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations.Scientific reports · 2023Article
- Dynamic fluctuations in ascending heart-to-brain communication under mental stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity.Frontiers in pharmacology · 2023Article
- Cardiac sympathetic-vagal activity initiates a functional brain-body response to emotional arousal.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Brain-heart interactions in the neurobiology of consciousness.Current research in neurobiology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Decision-making and representations of arousal are intimately linked. Behavioral investigations have classically shown that either too little or too much bodily arousal is detrimental to decision-making, indicating that there is an inverted "U" relationship between bodily arousal and performance. How these processes interact at the level of single neurons as well as the neural circuits involved are unclear. Here we recorded neural activity from orbitofrontal cortex (OFC) and dorsal anterior cingulate cortex (dACC) of macaque monkeys while they made reward-guided decisions. Heart rate (HR) was also recorded and used as a proxy for bodily arousal. Recordings were made both before and after subjects received excitotoxic lesions of the bilateral amygdala. In intact monkeys, higher HR facilitated reaction times (RTs). Concurrently, a set of neurons in OFC and dACC selectively encoded trial-by-trial variations in HR independent of reward value. After amygdala lesions, HR increased, and the relationship between HR and RTs was altered. Concurrent with this change, there was an increase in the proportion of dACC neurons encoding HR. Applying a population-coding analysis, we show that after bilateral amygdala lesions, the balance of encoding in dACC is skewed away from signaling either reward value or choice direction toward HR coding around the time that choices are made. Taken together, the present results provide insight into how bodily arousal and decision-making are signaled in frontal cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.