Evidence map›Paper›PMID 34452940›Full record

Trial reportBMJ global health2021

A cluster randomised trial of cookstove interventions to improve infant health in Ghana.

Darby W Jack, Kenneth Ayuurebobi Ae-Ngibise, Carlos F Gould, Ellen Boamah-Kaali, Alison G Lee, Mohammed Nuhu Mujtaba, Steven Chillrud, Seyram Kaali, Ashlinn K Quinn, Stephaney Gyaase and 13 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01335490 (Intervening to Improve Birth Weight and Infant Respiratory Health in Rural Ghana), which is not on this map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01335490 nacompletednot on this map

Intervening to Improve Birth Weight and Infant Respiratory Health in Rural Ghana

TypeinterventionalSponsorColumbia UniversityRan2013 to 2016Enrolled1,414ConditionsVery Low Birth Weight Baby, PneumoniaArmsCook stoves, either Biolite wood stove, or liquified petroleum gas stove plus fuel
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 2 countries.

Darby W JackDepartment of Environmental Health Sciences, Columbia University, New York, New York, USA dj2183@cumc.columbia.edu.ORCID 0000-0002-9932-0201
Kenneth Ayuurebobi Ae-NgibiseKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Carlos F GouldDepartment of Environmental Health Sciences, Columbia University, New York, New York, USA.
Ellen Boamah-KaaliKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Alison G LeeDivision of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mohammed Nuhu MujtabaKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Steven ChillrudLamont-Doherty Earth Observatory, Columbia University, Palisades, New York, USA.
Seyram KaaliKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Ashlinn K QuinnFogarty International Center, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-0050-2647
Stephaney GyaaseKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Felix Boakye OppongKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Daniel CarriónDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Oscar AgyeiKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Katrin BurkhartInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USA.
Joseph A Ana-AroKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Xinhua LiuDepartment of Biostatistics, Columbia University, New York, New York, USA.
Yvonne Afrah BerkoKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Blair J WylieCenter for Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Seeba Amenga EtegoKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Robin WhyattDepartment of Environmental Health Sciences, Columbia University, New York, New York, USA.
Seth Owusu-AgyeiUniversity of Health and Allied Sciences, Ho, Ghana.
Patrick KinneyDepartment of Environmental Health, Boston University, Boston, Massachusetts, USA.
Kwaku Poku AsanteKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.
Kintampo Health Research Centre · GHColumbia University · USIcahn School of Medicine at Mount Sinai · USBeth Israel Deaconess Medical Center · USBoston University · USLamont-Doherty Earth Observatory · USNational Institutes of Health · USUniversity of Health and Allied Sciences · GHUniversity of Washington · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Intervening to Improve Birth Weight and Infant Respiratory Health in Rural GhanaR01ES019547 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KINNEY, PATRICK LOTT · 2011 to 2016
$4.5M
Interdisciplinary Training in Climate and HealthT32ES023770 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAMAN, JEFFREY L · 2014 to 2019
$1.5M
Household air pollution in Tanzania, placental health and pregnancy outcomeK23ES021471 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI WYLIE, BLAIR JOHNSON · 2012 to 2016
$1.3M
Prenatal PM2.5 and programming of respiratory outcomes: Placental biomarkers and effect modification by stressK23HL135349 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, ALISON G · 2017 to 2021
$884k
High Precision Robotic Weighing System in Support of New Exposure Health StudiesS10OD016219 · OD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHILLRUD, STEVEN N. · 2013 to 2013
$250k
Estimating the health benefits of national clean cooking fuel scale-up: A case study in Ecuador using national health dataF31ES031833 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOULD, CARLOS · 2020 to 2020
$32k
NHLBI NIH HHS K23 HL135349NIEHS NIH HHS F31 ES031833NIEHS NIH HHS K23 ES021471NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES019547NIEHS NIH HHS T32 ES023770NIH HHS S10 OD016219
6 · The paper itself

Abstract

introductionHousehold air pollution from solid fuel combustion for cooking and heating is a leading cause of childhood morbidity and mortality worldwide. We hypothesised that clean cooking interventions delivered during pregnancy would improve child health.

methodsWe conducted a cluster randomised trial in rural Ghana to test whether providing pregnant women liquefied petroleum gas (LPG) cookstoves or improved biomass cookstoves would reduce personal carbon monoxide and fine particulate pollution exposure, increase birth weight and reduce physician-assessed severe pneumonia in the first 12 months of life, compared with control participants who continued to cook with traditional stoves. Primary analyses were intention-to-treat. The trial was registered with ClinicalTrials.gov and follow-up is complete.

resultsEnrolment began on 14 April 2014, and ended on 20 August 2015. We enrolled 1414 pregnant women; 361 in the LPG arm, 527 in the improved biomass cookstove arm and 526 controls. We saw no improvement in birth weight (the difference in mean birth weight for LPG arm births was 29 g lighter (95% CI -113 to 56, p=0.51) and for improved biomass arm births was 9 g heavier (95% CI -64 to 82, p=0.81), compared with control newborns) nor severe child pneumonia (the rate ratio for pneumonia in the LPG arm was 0.98 (95% CI 0.58 to 1.70; p=0.95) and for the improved biomass arm was 1.21 (95% CI 0.78 to 1.90; p=0.52), compared with the control arm). Air pollution exposures in the LPG arm remained above WHO health-based targets (LPG median particulate matter less than 2.5 microns in diameter (PM

conclusionsNeither prenatally-introduced LPG nor improved biomass cookstoves improved birth weight or reduced severe pneumonia risk in the first 12 months of life. We hypothesise that this is due to lower-than-expected exposure reductions in the intervention arms. TRIAL REGISTRATION NUMBER: NCT01335490.

Indexed as

Air Pollution, IndoorHousehold ArticlesCookingFemaleGhanaHumansInfantInfant HealthInfant, NewbornPregnancychild healthenvironmental healthepidemiologyrandomised control trial

Identifiers

PMID34452940
PMCPMC8404442
OpenAlexW3194777243

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.