Evidence map›Paper›PMID 34452925›Full record

ArticleScience immunology2021

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation.

Joshua M Moreau, Miqdad O Dhariwala, Victoire Gouirand, Devi P Boda, Ian C Boothby, Margaret M Lowe, Jarish N Cohen, Courtney E Macon, John M Leech, Lokesh A Kalekar and 2 more

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Research progress on T-cell responses inFrontiers in microbiology · 2026
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Treg-tissue cell interactions in repair and regeneration.The Journal of experimental medicine · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Regulatory T cells in dominant immunologic tolerance.The Journal of allergy and clinical immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Joshua M MoreauDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1227-1508
Miqdad O DhariwalaDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5716-4864
Victoire GouirandDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2666-0061
Devi P BodaDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2880-1657
Ian C BoothbyDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1112-2834
Margaret M LoweDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5623-7707
Jarish N CohenDepartment of Pathology, University of California at San Francisco, San Francisco, CA, 94143, USA.ORCID 0000-0002-6043-2177
Courtney E MaconDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
John M LeechDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8766-4915
Lokesh A KalekarDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8368-1291
Tiffany C ScharschmidtDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5517-089X
Michael D RosenblumDepartment of Dermatology, University of California at San Francisco, San Francisco, CA, USA. michael.rosenblum@ucsf.edu.ORCID 0000-0002-0462-5732
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Functional Manipulation of Memory Regulatory T cells in SkinDP2AR068130 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2014 to 2014
$2.4M
Elucidating the Cellular and Molecular Mechanisms of How Regulatory T cells in Skin Regulate Fibroblast Activation and Tissue FibrosisR01AR071944 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2018 to 2022
$1.7M
The role of regulatory T cells in early-life development and immunity of the skinF30AI147364 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOOTHBY, IAN · 2019 to 2022
$178k
NIAID NIH HHS F30 AI147364NIAMS NIH HHS DP2 AR068130NIAMS NIH HHS R01 AR071944NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Regulatory T cells (T

Indexed as

AnimalsImmunity, InnateInflammationMiceMice, CongenicMice, Inbred C57BLMice, TransgenicSkinT-Lymphocytes, RegulatoryTransforming Growth Factor betaTransforming Growth Factor beta

Identifiers

PMID34452925
PMCPMC8958044
OpenAlexW3195688520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.