Evidence map›Paper›PMID 34452914›Full record

ArticleScience advances2021

Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis.

Luis Hernandez-Nunez, Alicia Chen, Gonzalo Budelli, Matthew E Berck, Vincent Richter, Anna Rist, Andreas S Thum, Albert Cardona, Mason Klein, Paul Garrity and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  8. An Advanced Undergraduate Laboratory Course: Calcium Imaging and Data Analysis - a Mini Graduate Research Experience.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2025
    Article
  9. Pulsing Addition to Modulated Electro-Hyperthermia.Bioengineering (Basel, Switzerland) · 2024
    Review
  10. Review
  11. Article
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  13. Review
  14. Article
  15. The impacts of hypertonic conditions onFrontiers in cellular neuroscience · 2024
    Article
  16. Article
  17. The connectome of an insect brain.Science (New York, N.Y.) · 2023
    Article
  18. Article
  19. Article
  20. TACI: An ImageJ Plugin for 3D Calcium Imaging Analysis.Journal of visualized experiments : JoVE · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Luis Hernandez-NunezDepartment of Physics, Harvard University, Cambridge, MA 02138, USA. luishernandeznunez@fas.harvard.edu klein@miami.edu pgarrity@brandeis.edu samuel@physics.harvard.edu.ORCID http://orcid.org/0000-0003-3102-9036
Alicia ChenDepartment of Physics, Harvard University, Cambridge, MA 02138, USA.ORCID http://orcid.org/0000-0001-5521-8566
Gonzalo BudelliNational Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA.ORCID http://orcid.org/0000-0002-2157-5511
Matthew E BerckJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
Vincent RichterUniversity of Leipzig, Institute of Biology, Talstraße 33, 04103 Leipzig, Germany.ORCID http://orcid.org/0000-0001-8009-0357
Anna RistUniversity of Leipzig, Institute of Biology, Talstraße 33, 04103 Leipzig, Germany.
Andreas S ThumUniversity of Leipzig, Institute of Biology, Talstraße 33, 04103 Leipzig, Germany.ORCID http://orcid.org/0000-0002-3830-6596
Albert CardonaJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.ORCID http://orcid.org/0000-0003-4941-6536
Mason KleinDepartment of Physics, University of Miami, Coral Gables, FL 33124, USA. luishernandeznunez@fas.harvard.edu klein@miami.edu pgarrity@brandeis.edu samuel@physics.harvard.edu.ORCID http://orcid.org/0000-0001-8211-077X
Paul GarrityNational Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. luishernandeznunez@fas.harvard.edu klein@miami.edu pgarrity@brandeis.edu samuel@physics.harvard.edu.ORCID http://orcid.org/0000-0002-8274-6564
Aravinthan D T SamuelDepartment of Physics, Harvard University, Cambridge, MA 02138, USA. luishernandeznunez@fas.harvard.edu klein@miami.edu pgarrity@brandeis.edu samuel@physics.harvard.edu.ORCID http://orcid.org/0000-0002-1672-8720
Harvard University · USLeipzig University · DEBrandeis University · USHoward Hughes Medical Institute · USUniversity of Miami · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Molecular and cellular determinants of Drosophila larva thermotaxisR01GM130842 · NIGMS · BRANDEIS UNIVERSITY · PI Paul Garrity, ARAVINTHAN D. SAMUEL · 2019 to 2026
$3.8M
Medical Research Council MC_UP_1201/21NIGMS NIH HHS R01 GM130842NIH HHS P40 OD018537
6 · The paper itself

Abstract

Body temperature homeostasis is essential and reliant upon the integration of outputs from multiple classes of cooling- and warming-responsive cells. The computations that integrate these outputs are not understood. Here, we discover a set of warming cells (WCs) and show that the outputs of these WCs combine with previously described cooling cells (CCs) in a cross-inhibition computation to drive thermal homeostasis in larval

Identifiers

PMID34452914
PMCPMC8397275
OpenAlexW3194317557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.