Evidence map›Paper›PMID 34452686›Full record

ArticleAdvances in pharmacology (San Diego, Calif.)2021

Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.

Mary Jo Laws, Alison M Neff, Emily Brehm, Genoa R Warner, Jodi A Flaws

Open access · greenAbstract read
In one paragraph

Article in Advances in pharmacology (San Diego, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026
    Observational
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  18. Herbicide-related health risks: key mechanisms and a guide to mitigation strategies.Journal of occupational medicine and toxicology (London, England) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mary Jo LawsDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Alison M NeffDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Emily BrehmDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Genoa R WarnerDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Jodi A FlawsDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States. Electronic address: jflaws@illinois.edu.
University of Illinois Urbana-Champaign · US

Funding

Research Training Program in Toxicology and Environmental HealthT32ES007326 · NIEHS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jodi A. Flaws · 2000 to 2026
$8.7M
Phthalates and Ovarian ToxicityR01ES028661 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FLAWS, JODI A. · 2018 to 2022
$1.8M
Mechanisms of Phthalate Toxicity in the OvaryK99ES031150 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WARNER, GENOA R · 2020 to 2021
$194k
NIEHS NIH HHS K99 ES031150NIEHS NIH HHS R01 ES028661NIEHS NIH HHS T32 ES007326
6 · The paper itself

Abstract

This chapter covers the known effects of endocrine disrupting chemicals (EDCs) on reproductive disorders. The EDCs represented are highly studied, including plasticizers (bisphenols and phthalates), chemicals in personal care products (parabens), persistent environmental contaminants (polychlorinated biphenyls), and chemicals in pesticides or herbicides. Both female and male reproductive disorders are reviewed in the chapter. Female disorders include infertility/subfertility, irregular reproductive cycles, early menopause, premature ovarian insufficiency, polycystic ovarian syndrome, endometriosis, and uterine fibroids. Male disorders include infertility/subfertility, cryptorchidism, and hypospadias. Findings from both human and animal studies are represented.

Indexed as

Endocrine DisruptorsEnvironmental PollutantsAnimalsEnvironmental ExposureFemaleHumansMaleModels, AnimalEndocrine DisruptorsEnvironmental PollutantsBisphenolEndocrine disrupting chemicalFertilityParabenPerfluorochemicalPesticidesPhthalatePolychlorinated biphenylsReproductionReproductive system health

Identifiers

PMID34452686
PMCPMC9743013
OpenAlexW3157892565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.