Evidence map›Paper›PMID 34452579›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2021

Association of AXIN2 s2240308 C>T, rs1133683 C>T, rs7224837 A>G Polymorphisms with Susceptibility to Breast Cancer.

Soheila Sayad, Mahdieh Abdi-Gamsae, Jamal Jafari-Nedooshan, Meraj Farbod, Seyed Alireza Dastgheib, Mojgan Karimi-Zarchi, Fatemeh Asadian, Hossein Neamatzadeh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Soheila SayadDepartment of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Mahdieh Abdi-GamsaeDepartment of Biology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Jamal Jafari-NedooshanDepartment of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Meraj FarbodCancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mojgan Karimi-ZarchiDepartment of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh AsadianDepartment of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRShiraz University of Medical Sciences · IRImam Khomeini Hospital · IRIran University of Medical Sciences · IRIslamic Azad University, Shahr-e-Qods Branch · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association of genetic polymorphisms at Axis inhibition protein 2 (AXIN2) gene and susceptibility to different cancer has attracted much interest. The present study aimed to evaluate the association between AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms with susceptibility to breast cancer.

methodsA polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was designed to genotype the AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms among 150 breast cancer patients and 150 healthy subjects.

resultsThe frequencies of these genetic variants were in agreement with Hardy-Weinberg equilibrium in healthy controls (p>0.05). The frequencies of AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G genotypes were similar in breast cancer patients and controls. There was no a significant association between the AXIN2 SNP and risk of breast cancer.

conclusionThe impact of AXIN2 polymorphisms in the breast cancer development remains unclear. Our results indicated that AXIN2 rs2240308, rs7224837 and rs1133683 polymorphisms did not contribute to increased risk of breast cancer. More studies with larger sample sizes and diverse ethnicities are warranted to verify our finding.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAxin ProteinBiomarkers, TumorBreast NeoplasmsCase-Control StudiesFemaleFollow-Up StudiesGenotypeHumansIranPrognosisAXIN2 protein, humanAxin ProteinBiomarkers, TumorassociationAXIN2breast cancerpolymorphismsSusceptibility

Identifiers

PMID34452579
PMCPMC8629482
OpenAlexW3195690359

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.