Evidence map›Paper›PMID 34452506›Full record

ArticleViruses2021

The Role of Phylogenetics in Unravelling Patterns of HIV Transmission towards Epidemic Control: The Quebec Experience (2002-2020).

Bluma G Brenner, Ruxandra-Ilinca Ibanescu, Nathan Osman, Ernesto Cuadra-Foy, Maureen Oliveira, Antoine Chaillon, David Stephens, Isabelle Hardy, Jean-Pierre Routy, Réjean Thomas and 5 more

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Action needed to address molecular HIV surveillance ethical concerns.Canadian journal of public health = Revue canadienne de sante publique · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bluma G BrennerMcGill Centre for Viral Diseases, Lady Davis Institute for Medical Research, Montréal, QC H3T 1E2, Canada.ORCID 0000-0002-2084-728X
Ruxandra-Ilinca IbanescuMcGill Centre for Viral Diseases, Lady Davis Institute for Medical Research, Montréal, QC H3T 1E2, Canada.
Nathan OsmanMcGill Centre for Viral Diseases, Lady Davis Institute for Medical Research, Montréal, QC H3T 1E2, Canada.
Ernesto Cuadra-FoyMcGill Centre for Viral Diseases, Lady Davis Institute for Medical Research, Montréal, QC H3T 1E2, Canada.
Maureen OliveiraMcGill Centre for Viral Diseases, Lady Davis Institute for Medical Research, Montréal, QC H3T 1E2, Canada.
Antoine ChaillonDepartment of Medicine, University of California, San Diego, CA 93903, USA.
David StephensDepartment of Mathematics and Statistics, McGill University, Montréal, QC H3A 0B9, Canada.ORCID 0000-0001-9811-7140
Isabelle HardyDépartement de Microbiologie et d'Immunologie et Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC H2X 0C1, Canada.
Jean-Pierre RoutyChronic Viral Illness Service, McGill University Health Centre, Montréal, QC H3A 3J1, Canada.ORCID 0000-0001-9897-7589
Réjean ThomasClinique Médicale l'Actuel, Montréal, QC H2L 4P9, Canada.
Jean-Guy BarilClinique Médicale Urbaine du Quartier Latin, Montréal, QC H2L 4E9, Canada.
Roger LeblancClinique Médicale OPUS, Montréal, QC H3A 1T1, Canada.
Cecile TremblayDépartement de Microbiologie et d'Immunologie et Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC H2X 0C1, Canada.
Michel RogerDépartement de Microbiologie et d'Immunologie et Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC H2X 0C1, Canada.
The Montreal Primary Hiv Infection Phi Cohort Study GroupMontreal PHI Cohort of the Réseau Sida et Maladies Infectieuses, Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI036214
6 · The paper itself

Abstract

Phylogenetics has been advanced as a structural framework to infer evolving trends in the regional spread of HIV-1 and guide public health interventions. In Quebec, molecular network analyses tracked HIV transmission dynamics from 2002-2020 using MEGA10-Neighbour-joining, HIV-TRACE, and MicrobeTrace methodologies. Phylogenetics revealed three patterns of viral spread among Men having Sex with Men (MSM,

Indexed as

PhylogenyAdultAgedAged, 80 and overEpidemicsFemaleHIV-1HIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedQuebecYoung AdultHIV-1 transmissionHIV-TRACEmen having sex with menmigrationnon-B subtypesphylogeneticstreatment-as-prevention

Identifiers

PMID34452506
PMCPMC8402830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.