Evidence map›Paper›PMID 34452471›Full record

ArticleViruses2021

Retrospective Study of the Upsurge of Enterovirus D68 Clade D1 among Adults (2014-2018).

Maxime Duval, Audrey Mirand, Olivier Lesens, Jacques-Olivier Bay, Denis Caillaud, Denis Gallot, Alexandre Lautrette, Sylvie Montcouquiol, Jeannot Schmidt, Carole Egron and 6 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Prospective use of wastewater surveillance for early detection of enterovirus D68 in community outbreaks among children, Niigata City, Japan, 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  3. Article
  4. Article
  5. Incidence, clinical manifestations and characterization of Enterovirus in the last decade (2014-2023) in Asturias (Spain). Effect of the SARS-CoV-2 pandemic.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  6. Article
  7. Article
  8. Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Maxime DuvalUniversité Clermont Auvergne, LMGE CNRS 6023, UFR de Médecine et des Professions Paramédicales, 63001 Clermont-Ferrand, France.
Audrey MirandUniversité Clermont Auvergne, LMGE CNRS 6023, UFR de Médecine et des Professions Paramédicales, 63001 Clermont-Ferrand, France.
Olivier LesensCHU Clermont-Ferrand, Service Des Maladies Infectieuses et Tropicales, 63003 Clermont-Ferrand, France.
Jacques-Olivier BayCHU Clermont-Ferrand, Service de Thérapie Cellulaire et Hématologie Clinique, 63003 Clermont-Ferrand, France.
Denis CaillaudCHU Clermont-Ferrand, Service de Pneumologie, 63003 Clermont-Ferrand, France.
Denis GallotCHU Clermont-Ferrand, Service de Gynécologie-Obstétrique, 63003 Clermont-Ferrand, France.
Alexandre LautretteService de Réanimation, Centre Jean Perrin, 63003 Clermont-Ferrand, France.
Sylvie MontcouquiolCHU Clermont-Ferrand, Centre de Référence et de Compétence Mucoviscidose, 63003 Clermont-Ferrand, France.
Jeannot SchmidtCHU Clermont-Ferrand, Service Des Urgences, 63003 Clermont-Ferrand, France.ORCID 0000-0003-3424-337X
Carole EgronCHU Clermont-Ferrand, Service de Pédiatrie Générale, 63003 Clermont-Ferrand, France.
Gwendoline JugieUniversité Clermont Auvergne, LMGE CNRS 6023, UFR de Médecine et des Professions Paramédicales, 63001 Clermont-Ferrand, France.
Maxime BisseuxUniversité Clermont Auvergne, LMGE CNRS 6023, UFR de Médecine et des Professions Paramédicales, 63001 Clermont-Ferrand, France.
Christine ArchimbaudUniversité Clermont Auvergne, LMGE CNRS 6023, UFR de Médecine et des Professions Paramédicales, 63001 Clermont-Ferrand, France.
Céline LambertCHU Clermont-Ferrand, Service Biométrie et Médico-Economie-Direction de la Recherche Clinique et Innovation, 63003 Clermont-Ferrand, France.ORCID 0000-0002-6459-4800
Cécile HenquellUniversité Clermont Auvergne, LMGE CNRS 6023, UFR de Médecine et des Professions Paramédicales, 63001 Clermont-Ferrand, France.
Jean-Luc BaillyUniversité Clermont Auvergne, LMGE CNRS 6023, UFR de Médecine et des Professions Paramédicales, 63001 Clermont-Ferrand, France.
Centre Hospitalier Universitaire de Clermont-Ferrand · FRCentre National de la Recherche Scientifique · FRCentre Jean Perrin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterovirus D68 (EV-D68) has emerged as an agent of epidemic respiratory illness and acute flaccid myelitis in the paediatric population but data are lacking in adult patients. We performed a 4.5-year single-centre retrospective study of all patients who tested positive for EV-D68 and analysed full-length EV-D68 genomes of the predominant clades B3 and D1. Between 1 June 2014, and 31 December 2018, 73 of the 11,365 patients investigated for respiratory pathogens tested positive for EV-D68, of whom 20 (27%) were adults (median age 53.7 years [IQR 34.0-65.7]) and 53 (73%) were children (median age 1.9 years [IQR 0.2-4.0]). The proportion of adults increased from 12% in 2014 to 48% in 2018 (

Indexed as

AdultAgedCentral Nervous System Viral DiseasesChild, PreschoolDNA, ViralEnterovirus D, HumanEnterovirus InfectionsFemaleFranceGenome, ViralHumansInfantMaleMiddle AgedMyelitisNeuromuscular DiseasesDNA, Viraladult patientsenterovirus D68molecular epidemiologynext-generation sequencingpaediatric patientsrespiratory conditions

Identifiers

PMID34452471
PMCPMC8402803
OpenAlexW3194847799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.