ArticleViruses2021
The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response.
Open access · goldAbstract readConsensus Statement
In one paragraph
Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Ebola Virus Disease in the Era of One Health and Global Preparedness: Evolving Epidemiology, Genomic Surveillance, and Future Challenges.Infectious disease reports · 2026Review
- Review
- Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.Nature microbiology · 2024Article
- Quantitatively assessing early detection strategies for mitigating COVID-19 and future pandemics.Nature communications · 2023Article
- Quantitatively assessing early detection strategies for mitigating COVID-19 and future pandemics.medRxiv : the preprint server for health sciences · 2023Article
- Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.Nature communications · 2023Article
- Article
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Authors and funding
111 authors at 19 institutions in 4 countries.
Yolanda Botti-LodovicoBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Parvathy NairHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Dolo NosamiefanAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Matthew StremlauEquator Labs Incorporated, Washington, DC 20011, USA.
Stephen SchaffnerBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-6699-3568
Sebastian V AgignoaeBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
John Oke AiyepadaInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Fehintola V AjogbasileAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
George O AkpedeInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Foday AlhasanViral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.
Kristian G AndersenDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Danny A AsogunAmbrose Alli University, Ekpoma, Edo State, Nigeria.
Oladele Oluwafemi AyodejiFederal Medical Centre, Owo, Ondo State, Nigeria.
Aida S BadianeUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Kayla BarnesBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Matthew R BauerDivision of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
Antoinette Bell-KareemTulane University Medical Center, New Orleans, LA 70112, USA.
Muoebonam Ekene BenardInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Ebo Ohomoime BenevolenceInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Osiemi BlessingInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Chloe K BoehmBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Matthew L BoisenZalgen Labs, Germantown, MD 20876, USA.
Nell G BondTulane University Medical Center, New Orleans, LA 70112, USA.
Luis M BrancoZalgen Labs, Germantown, MD 20876, USA.
Michael J ButtsBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Amber CarterBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Andres ColubriBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Awa B DemeUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Katherine C DeRuffBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Younousse DiédhiouUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Akhilomen Patience EdamhandeInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Siham ElhamoumiBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Emily J EngelTulane University Medical Center, New Orleans, LA 70112, USA.
Philomena EromonAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Mosoka FallahRefuge Place International, Bassa Town, Lower Johnsonville, Liberia.
Onikepe A FolarinAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Ben FryFathom Information Design, Boston, MA 02114, USA.
Robert GarryTulane University Medical Center, New Orleans, LA 70112, USA.ORCID 0000-0002-5683-3250
Amy GayeUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Michael GbakieViral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.
Sahr M GevaoUniversity of Sierra Leone, Freetown, Sierra Leone.
Gabrielle GionetBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Adrianne Gladden-YoungBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Augustine GobaCollege of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
Jules Francois GomisUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Anise N HappiAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Mary HoughtonBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Chikwe IhekwuazuInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Christopher Ojemiega IruolagbeDepartment of Internal Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Jonathan JacksonDimagi, Inc., Cambridge, MA 02139, USA.
Simbirie JallohCollege of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
Jeremy JohnsonBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Lansana KannehViral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.
Adeyemi KayodeAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Molly KemballBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Ojide Chiedozie KingsleyDepartment of Medical Microbiology, Alex-Ekwueme Federal University Teaching Hospital Abakaliki, Abakaliki, Ebonyi, Nigeria.
Veronica KoromaViral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.
Dylan KotliarBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Samar MehtaDepartment of Critical Care Medicine, University of Maryland Medical Center, Baltimore, MA 21201, USA.
Hayden C MetskyBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Airende MichaelInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Marzieh Ezzaty MirhashemiBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Kayvon ModjarradWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Mambu MomohCollege of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
Cameron A MyhrvoldBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-8971-184X
Okonofua Grace NaregoseInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Tolla NdiayeUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Mouhamadou NdiayeUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Aliou NdiayeUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Erica NormandinBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Ikponmwosa OdiaInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Judith Uche OguzieAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Sylvanus A OkogbeninInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Peter O OkokhereInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Johnson OkolieAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Idowu B OlawoyeAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Testimony J OlumadeAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Paul E OluniyiAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Omigie OmoregieInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Daniel J ParkBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-7226-7781
Mariétou Faye PayeBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Brittany PetrosBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Anthony A PhilippakisBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Abechi PriscillaAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Alan RicksMASS Design Group, Boston, MA 02116, USA.
Anne RimoinDepartment of Epidemiology, Jonathan and Karing Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
John Demby SandiCollege of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
John S SchieffelinSection of Infectious Disease, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Monica SchreiberDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Mame Cheikh SeckUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Sameed SiddiquiBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Katherine SiddleBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Allison R SmitherDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Mouhamad SyUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Ngayo SyUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Christopher H Tomkins-TinchBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Oyewale TomoriInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Chinedu UgwuAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.ORCID 0000-0002-6347-1593
Jessica N UwanibeAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Eghosasere Anthonia UyigueInstitute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Dada Ireti VictoriaAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Anika VinzéBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Megan E VodzakBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Nicole WelchBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Haja Isatta WurieCollege of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
Daba ZoumarouUniversité Cheikh Anta Diop, BP 5005, Dakar, Senegal.
Donald S GrantViral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.
Daouda NdiayeDepartment of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.
Bronwyn MacInnisBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Pardis C SabetiBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
Christian HappiAfrican Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
Broad Institute · USRedeemer's University · NGIrrua Specialist Teaching Hospital · NGCheikh Anta Diop University · SNUniversity of Sierra Leone · SLTulane University · USHarvard University · USZalgen (United States) · USAmbrose Alli University · NGDimagi (United States) · USFederal Medical Centre · NGFederal Teaching Hospital Abakaliki · NGHoward Hughes Medical Institute · USScripps Research Institute · USUniversity of California, Los Angeles · USUniversity of Maryland, Baltimore · USWalter Reed Army Institute of Research · USWest African College of Physicians · NGYale University · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MNIGMS NIH HHS T32 GM007753
Abstract
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE-detected in the Yoruba population of Nigeria-conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the "emerging" nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz's critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
Indexed as
Disaster PlanningAfrica, WesternHumansLassa FeverLassa virusN-AcetylglucosaminyltransferasesNigeriaPandemicsPolymorphism, GeneticReceptors, VirusLARGE1 protein, humanN-AcetylglucosaminyltransferasesReceptors, Virusbioinformaticsdiagnostic toolsEbolagenomic surveillanceinfectious diseaseLARGELassa feverLassa viruspandemic preemptionpandemic response
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