Evidence map›Paper›PMID 34452378›Full record

ArticleViruses2021

Epidemiology and Seasonality of Endemic Human Coronaviruses in South African and Zambian Children: A Case-Control Pneumonia Study.

Vicky L Baillie, David P Moore, Azwifarwi Mathunjwa, Daniel E Park, Donald M Thea, Geoffrey Kwenda, Lawrence Mwananyanda, Shabir A Madhi

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Vicky L BaillieMedical Research Council: Vaccines and Infectious Diseases Analytics, University of the Witwatersrand, Johannesburg 2050, South Africa.ORCID 0000-0003-1327-9090
David P MooreMedical Research Council: Vaccines and Infectious Diseases Analytics, University of the Witwatersrand, Johannesburg 2050, South Africa.
Azwifarwi MathunjwaMedical Research Council: Vaccines and Infectious Diseases Analytics, University of the Witwatersrand, Johannesburg 2050, South Africa.
Daniel E ParkDepartment of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0001-5139-5397
Donald M TheaDepartment of Global Health, Boston University School of Public Health, Boston, MA 02118, USA.
Geoffrey KwendaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka 50110, Zambia.
Lawrence MwananyandaRight to Care-Zambia, Department of Global Health, Boston University School of Public Health, Boston, MA 02118, USA.
Shabir A MadhiMedical Research Council: Vaccines and Infectious Diseases Analytics, University of the Witwatersrand, Johannesburg 2050, South Africa.
University of the Witwatersrand · ZABoston University · USMilken Institute · USUniversity of Zambia · ZM

Funding

Bill and Melinda Gates Foundation 48968
6 · The paper itself

Abstract

Endemic human coronaviruses (HCoV) are capable of causing a range of diseases from the common cold to pneumonia. We evaluated the epidemiology and seasonality of endemic HCoVs in children hospitalized with clinical pneumonia and among community controls living in countries with a high HIV burden, namely South Africa and Zambia, between August 2011 to October 2013. Nasopharyngeal/oropharyngeal swabs were collected from all cases and controls and tested for endemic HCoV species and 12 other respiratory viruses using a multiplex real-time PCR assay. We found that the likelihood of detecting endemic HCoV species was higher among asymptomatic controls than cases (11% vs. 7.2%; 95% CI: 1.2-2.0). This was however only observed among children > 6 months and was mainly driven by the

Indexed as

Case-Control StudiesChildChild, PreschoolCoronavirusCoronavirus InfectionsHospitalizationHumansInfantMaleNasopharynxRespiratory Tract InfectionsSeasonsSouth AfricaZambiachildhoodcoronavirusepidemiologypneumonia

Identifiers

PMID34452378
PMCPMC8402793
OpenAlexW3187222426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.