Evidence map›Paper›PMID 34452374›Full record

ReviewViruses2021

Common Themes in Zoonotic Spillover and Disease Emergence: Lessons Learned from Bat- and Rodent-Borne RNA Viruses.

Evan P Williams, Briana M Spruill-Harrell, Mariah K Taylor, Jasper Lee, Ashley V Nywening, Zemin Yang, Jacob H Nichols, Jeremy V Camp, Robert D Owen, Colleen B Jonsson

Abstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Extensive longevity and DNA virus-driven adaptation in nearcticbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Review
  12. Bat Rhabdoviruses: occurrence, detection and challenges in Africa.Tropical animal health and production · 2025
    Review
  13. Article
  14. Comprehensive Review on Viral RNA Extraction Strategies for Enhanced Molecular Diagnostics.Interdisciplinary perspectives on infectious diseases · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. WILDbase: towards a common database to improve wildlife disease surveillance in Europe.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  19. Article
  20. External quality assessment of orthohantavirus and lymphocytic choriomeningitis virus molecular detection and serology in Europe, 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Evan P WilliamsDepartment of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-4506-115X
Briana M Spruill-HarrellDepartment of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Mariah K TaylorDepartment of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-2378-9350
Jasper LeeDepartment of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ashley V NyweningDepartment of Clinical Pharmacy and Translational Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-4969-4192
Zemin YangDepartment of Cell and Molecular Biology, St. Jude's Children's Hospital, Memphis, TN 38105, USA.
Jacob H NicholsDepartment of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jeremy V CampCenter for Virology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-9040-5786
Robert D OwenCentro para el Desarrollo de Investigaciones Científicas, Asunción C.P. 1371, Paraguay.ORCID 0000-0002-0571-4606
Colleen B JonssonDepartment of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-2640-7672

Funding

Evolutonary Mechanisms of RNA Virus Host SwitchingR01AI103053 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI JONSSON, COLLEEN B · 2014 to 2017
$1.7M
6 · The paper itself

Abstract

Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest percentage of living mammals on earth. Thus, it is not surprising that these two orders account for many of the reservoirs of the zoonotic RNA viruses discovered to date. The spillover of these viruses from wildlife to human do not typically result in pandemics but rather geographically confined outbreaks of human infection and disease. While limited geographically, these viruses cause thousands of cases of human disease each year. In this review, we focus on three questions regarding zoonotic viruses that originate in bats and rodents. First, what biological strategies have evolved that allow RNA viruses to reside in bats and rodents? Second, what are the environmental and ecological causes that drive viral spillover? Third, how does virus spillover occur from bats and rodents to humans?

Indexed as

AnimalsChiropteraDisease OutbreaksDisease ReservoirsHumansRodentiaVirus DiseasesZoonosesbatsoutbreakreservoirRNA virusesrodentsspilloverzoonosis

Identifiers

PMID34452374
PMCPMC8402684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.