Evidence map›Paper›PMID 34452354›Full record

ArticleViruses2021

Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening.

Michael Kirstgen, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Karl-Heinz Baringhaus, Reimar Krieg, Dieter Glebe and 1 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Molecular mechanisms of NaBiophysical journal · 2024
    Article
  4. Article
  5. Article
  6. Multitasking NaBiomedicines · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Michael KirstgenInstitute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.
Simon Franz MüllerInstitute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-5429-0088
Kira Alessandra Alicia Theresa LowjagaInstitute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.
Nora GoldmannInstitute of Medical Virology, National Reference Center for Hepatitis B Viruses and Hepatitis D Viruses, Justus Liebig University Giessen, 35392 Giessen, Germany.
Felix LehmannInstitute of Medical Virology, National Reference Center for Hepatitis B Viruses and Hepatitis D Viruses, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-0259-0062
Sami AlakurttiDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, FI-00014 Helsinki, Finland.
Jari Yli-KauhaluomaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, FI-00014 Helsinki, Finland.ORCID 0000-0003-0370-7653
Karl-Heinz BaringhausSanofi-Aventis Deutschland GmbH, 65926 Frankfurt, Germany.
Reimar KriegInstitute of Anatomy II, University Hospital Jena, Teichgraben 7, 07743 Jena, Germany.
Dieter GlebeInstitute of Medical Virology, National Reference Center for Hepatitis B Viruses and Hepatitis D Viruses, Justus Liebig University Giessen, 35392 Giessen, Germany.
Joachim GeyerInstitute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0003-2663-1858
Justus-Liebig-Universität Gießen · DEUniversity of Helsinki · FIJena University Hospital · DESanofi (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hepatic bile acid transporter Na

Indexed as

User-Computer InterfaceAntiviral AgentsDrug DiscoveryHEK293 CellsHepatitis B virusHepatitis Delta VirusHepatocytesHep G2 CellsHumansInhibitory Concentration 50Organic Anion Transporters, Sodium-DependentQuantitative Structure-Activity RelationshipVirus AttachmentVirus InternalizationAntiviral AgentsOrganic Anion Transporters, Sodium-Dependententry inhibitorHBVHDVNTCPpharmacophoreQSARvirtual screen

Identifiers

PMID34452354
PMCPMC8402622
OpenAlexW3183705361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.