Evidence map›Paper›PMID 34452330›Full record

ArticleViruses2021

Evidence of Adaptive Evolution in

Tamanash Bhattacharya, Danny W Rice, John M Crawford, Richard W Hardy, Irene L G Newton

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tamanash BhattacharyaDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405, USA.ORCID 0000-0002-8129-7568
Danny W RiceDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405, USA.ORCID 0000-0002-1123-4617
John M CrawfordDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405, USA.
Richard W HardyDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405, USA.
Irene L G NewtonDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405, USA.ORCID 0000-0002-7118-0374
Indiana University Bloomington · USFred Hutch Cancer Center · US

Funding

Identifying Wolbachia effectors that facilitate host infectionR01AI144430 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI Irene Newton · 2019 to 2026
$3.0M
Type IV Secretion in an Obligate SymbiontR21AI137918 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI NEWTON, IRENE · 2018 to 2019
$443k
Epitranscriptomic Regulation of Alphavirus Replication and TransmissionR21AI153785 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI HARDY, RICHARD W · 2020 to 2021
$422k
NIAID NIH HHS R01 AI144430NIAID NIH HHS R21 AI137918NIAID NIH HHS R21 AI153785
6 · The paper itself

Abstract

Eukaryotic nucleic acid methyltransferase (MTase) proteins are essential mediators of epigenetic and epitranscriptomic regulation. DNMT2 belongs to a large, conserved family of DNA MTases found in many organisms, including holometabolous insects such as fruit flies and mosquitoes, where it is the lone MTase. Interestingly, despite its nomenclature, DNMT2 is not a DNA MTase, but instead targets and methylates RNA species. A growing body of literature suggests that DNMT2 mediates the host immune response against a wide range of pathogens, including RNA viruses. Curiously, although DNMT2 is antiviral in

Indexed as

Host-Pathogen InteractionsAdaptation, BiologicalAedesAmino Acid SequenceAnimalsDipteraDNA (Cytosine-5-)-MethyltransferasesDrosophila melanogasterDrosophila ProteinsEvolution, MolecularPhylogenyProtein ConformationSequence AlignmentWolbachiaDNA (Cytosine-5-)-MethyltransferasesDrosophila ProteinsMt2 protein, Drosophilaadaptive evolutionculicidaedipteradrosophilidaemethyltransferaseviruswolbachia

Identifiers

PMID34452330
PMCPMC8402854
OpenAlexW3185010809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.