Evidence map›Paper›PMID 34452321›Full record

ArticleViruses2021

Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes.

Petra C Fay, Fauziah Mohd Jaafar, Carrie Batten, Houssam Attoui, Keith Saunders, George P Lomonossoff, Elizabeth Reid, Daniel Horton, Sushila Maan, David Haig and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  16. Review
  17. Increased Clinical Signs and Mortality in IFNARPathogens (Basel, Switzerland) · 2023
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Petra C FaySchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK.ORCID 0000-0001-5808-4284
Fauziah Mohd JaafarUMR VIROLOGIE 1161, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, F-94700 Maisons-Alfort, France.
Carrie BattenThe Pirbright Institute, Surrey, Woking GU24 ONF, UK.ORCID 0000-0003-4274-7375
Houssam AttouiUMR VIROLOGIE 1161, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, F-94700 Maisons-Alfort, France.ORCID 0000-0001-9639-9981
Keith SaundersJohn Innes Centre, Department of Biochemistry and Metabolism, Norwich Research Park, Norwich NR4 7UH, UK.ORCID 0000-0002-5606-9627
George P LomonossoffJohn Innes Centre, Department of Biochemistry and Metabolism, Norwich Research Park, Norwich NR4 7UH, UK.ORCID 0000-0003-0700-906X
Elizabeth ReidSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK.
Daniel HortonPathology and Infectious Diseases, School of Veterinary Medicine, University of Surrey, Guildford GU2 7XH, UK.
Sushila MaanDepartment of Animal Biotechnology, Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar 125004, India.
David HaigSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK.
Janet M DalySchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK.ORCID 0000-0002-1912-4500
Peter P C MertensSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK.
University of Nottingham · GBÉcole Nationale Vétérinaire d'Alfort · FRJohn Innes Centre · GBThe Pirbright Institute · GBLala Lajpat Rai University of Veterinary and Animal Sciences · INUniversity of Surrey · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00001877
6 · The paper itself

Abstract

Bluetongue (BT) is a severe and economically important disease of ruminants that is widely distributed around the world, caused by the bluetongue virus (BTV). More than 28 different BTV serotypes have been identified in serum neutralisation tests (SNT), which, along with geographic variants (topotypes) within each serotype, reflect differences in BTV outer-capsid protein VP2. VP2 is the primary target for neutralising antibodies, although the basis for cross-reactions and serological variations between and within BTV serotypes is poorly understood. Recombinant BTV VP2 proteins (rVP2) were expressed in

Indexed as

SerogroupAnimalsAntigens, ViralBluetongueBluetongue virusCapsid ProteinsCross ReactionsEnzyme-Linked Immunosorbent AssayFemaleNicotianaRabbitsRuminantsSerotypingSheepAntigens, ViralCapsid ProteinsVP2 protein, Bluetongue virusantigenic cartographyBluetongue virusBTVcross-serotype antibodiesorbivirusorbivirus serotypesplant expressed proteinsVP2

Identifiers

PMID34452321
PMCPMC8402635
OpenAlexW3186027711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.