Evidence map›Paper›PMID 34452310›Full record

ArticleViruses2021

An Outbreak of Dengue Virus Serotype 2 Cosmopolitan Genotype in Nepal, 2017.

Mya Myat Ngwe Tun, Kishor Pandey, Takeshi Nabeshima, Aung Kyaw Kyaw, Mandira Adhikari, Sandra Kendra Raini, Shingo Inoue, Shyam Prakash Dumre, Basu Dev Pandey, Kouichi Morita

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mya Myat Ngwe TunDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Kishor PandeyCentral Department of Zoology, Institute of Science and Technology, Tribhuvan University, Kathmandu 44060, Nepal.ORCID 0000-0002-0619-9108
Takeshi NabeshimaDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Aung Kyaw KyawDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0002-1384-8030
Mandira AdhikariShi-Gan International College of Science and Technology, Kathmandu 44060, Nepal.
Sandra Kendra RainiDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Shingo InoueDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Shyam Prakash DumreCentral Department of Microbiology, Institute of Science and Technology, Tribhuvan University, Kirtipur 44618, Nepal.ORCID 0000-0002-4072-0745
Basu Dev PandeyMinistry of Health and Population, Kathmandu 44060, Nepal.
Kouichi MoritaDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Nagasaki University · JPTribhuvan University · NPMinistry of Health and Population · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) is one of the most prevalent neglected tropical diseases, with half of the world's population at risk of infection. In Nepal, DENV was first reported in 2004, and its prevalence is increasing every year. The present study aimed to obtain and characterize the full-length genome sequence of DENV from the 2017 outbreak. Hospital-based surveillance was conducted in two provinces of Nepal during the outbreak. Acute-phase serum samples were collected from 141 clinically suspected dengue patients after the rainy season. By serological and molecular techniques, 37 (26.9%) and 49 (34.8%), respectively, were confirmed as dengue patients. The cosmopolitan genotype of DENV-2 was isolated from 27 laboratory-confirmed dengue patients. Genomic analysis showed many amino acid substitutions distributed mainly among the E, NS3, and NS5 genes. Phylogenetic analyses of the whole genome sequence revealed two clades (Asian and Indian) among DENV-2 isolates from Nepal. The DENV isolates from hilly and Terai areas were similar to Asian and Indian strains, respectively. Further genomic study on different DENV serotypes is warranted to understand DENV epidemics in Nepal, where there are limited scientific resources and infrastructure.

Indexed as

GenotypeAdolescentAdultAgedChildChild, PreschoolCross-Sectional StudiesDengueDengue VirusDisease OutbreaksFemaleHumansInfantMaleMiddle AgedNepalcosmopolitan genotypedenguedengue virus serotype 2Nepalwhole genome sequencing

Identifiers

PMID34452310
PMCPMC8402744
OpenAlexW3184922434

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.