Evidence map›Paper›PMID 34452303›Full record

ArticleViruses2021

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.

Fauziah Mohd Jaafar, Baptiste Monsion, Mourad Belhouchet, Peter P C Mertens, Houssam Attoui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Increased Clinical Signs and Mortality in IFNARPathogens (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Fauziah Mohd JaafarUMR Virologie 1161, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
Baptiste MonsionUMR Virologie 1161, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.ORCID 0000-0002-5174-4742
Mourad BelhouchetDivision of Structural Biology, Henry Wellcome Building for Genomic Medicine, Oxford OX3 7BN, UK.
Peter P C MertensSutton Bonington Campus, School of Veterinary Medicine and Science, University of Nottingham, Leicestershire LE12 5RD, UK.
Houssam AttouiUMR Virologie 1161, INRAE, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France.
École Nationale Vétérinaire d'Alfort · FRCentre for Human Genetics · GBUniversity of Nottingham · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00001446
6 · The paper itself

Abstract

Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV,

Indexed as

AnimalsAntiviral AgentsBluetongueBluetongue virusCell LineCeratopogonidaeFluvastatinHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesMetabolic Networks and PathwaysMevalonic AcidMiceOrbivirusReceptor, Interferon alpha-betaViral LoadAntiviral AgentsFluvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesIfnar1 protein, mouseMevalonic AcidReceptor, Interferon alpha-betaantiviralbluetongue virusBTVfluvastatinHMG-CoA reductaseIFNAR(−/−) miceorbivirus

Identifiers

PMID34452303
PMCPMC8402872
OpenAlexW3185030485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.