Evidence map›Paper›PMID 34452293›Full record

ArticleViruses2021

Neurodevelopment in Children Exposed to Zika Virus: What Are the Consequences for Children Who Do Not Present with Microcephaly at Birth?

Paula Fabiana Sobral da Silva, Sophie Helena Eickmann, Ricardo Arraes de Alencar Ximenes, Celina Maria Turchi Martelli, Elizabeth B Brickley, Marília C Lima, Ulisses R Montarroyos, Maria Durce Costa Gomes de Carvalho, Laura Cunha Rodrigues, Thalia Velho Barreto de Araújo and 5 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Macaque Models of Prenatal and Postnatal Zika Virus Exposure and Developmental Outcomes.Journal of the Pediatric Infectious Diseases Society · 2025
    Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Paula Fabiana Sobral da SilvaPós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
Sophie Helena EickmannDepartamento de Pediatria, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.ORCID 0000-0002-6523-2107
Ricardo Arraes de Alencar XimenesPós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
Celina Maria Turchi MartelliInstituto Aggeu Magalhães-Fundação Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil.ORCID 0000-0002-2491-0688
Elizabeth B BrickleyDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0003-0280-2288
Marília C LimaDepartamento de Pediatria, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.
Ulisses R MontarroyosPós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
Maria Durce Costa Gomes de CarvalhoPós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
Laura Cunha RodriguesDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Thalia Velho Barreto de AraújoDepartamento de Medicina Social, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.
Liana O VenturaDepartamento de Oftalmologia, Fundação Altino Ventura, Recife 52171-011, Brazil.
Danielle Maria da Silva OliveiraPós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
Regina Coeli Ferreira RamosDepartamento de Infectologia Pediátrica, Hospital Universitário Oswaldo Cruz, Recife 50100-130, Brazil.
Demócrito de Barros Miranda-FilhoPós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
On Behalf Of The Microcephaly Epidemic Research Group Merg
Universidade de Pernambuco · BRHospital Universitário Oswaldo Cruz · BRUniversidade Federal de Pernambuco · BRLondon School of Hygiene & Tropical Medicine · GBFundação Altino Ventura · BRFundação Oswaldo Cruz · BR

Funding

Medical Research Council MC_PC_15088
6 · The paper itself

Abstract

The relation of Zika virus (ZIKV) with microcephaly is well established. However, knowledge is lacking on later developmental outcomes in children with evidence of maternal ZIKV infection during pregnancy born without microcephaly. The objective of this analysis is to investigate the impact of prenatal exposure to ZIKV on neuropsychomotor development in children without microcephaly. We evaluated 274 children including 235 ZIKV exposed and 39 controls using the Bayley-III Scales of Infant and Toddler Development (BSIDIII) and neurological examination. We observed a difference in cognition with a borderline p-value (

Indexed as

CognitionLanguage DevelopmentMotor SkillsPregnancy Complications, InfectiousZika Virus InfectionChild, PreschoolCross-Sectional StudiesDevelopmental DisabilitiesFemaleHumansMalePregnancyPrenatal Exposure Delayed EffectsBayley scaleschild developmentcongenital Zikaneuroclinical examinationpaediatric cohort

Identifiers

PMID34452293
PMCPMC8402706
OpenAlexW3183403697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.