Evidence map›Paper›PMID 34452282›Full record

ReviewPharmaceutics2021

Nanocarriers as a Tool for the Treatment of Colorectal Cancer.

Ana Luiza C de S L Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J Cruz, Raimundo Fernandes de Araújo Junior

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana Luiza C de S L OliveiraPostgraduate Program in Health Science, Federal University of Rio Grande do Norte (UFRN), Natal 59064-720, Brazil.ORCID 0000-0001-8692-9352
Timo SchomannTranslational Nanobiomaterials and Imaging (TNI) Group, Radiology Department, Leiden University Medical Center, 9600 Leiden, The Netherlands.ORCID 0000-0002-0948-6209
Lioe-Fee de Geus-OeiDepartment of Radiology, Leiden University Medical Center, 9600 Leiden, The Netherlands.ORCID 0000-0003-1817-2743
Ellen KapiteijnDepartment of Medical Oncology, Leiden University Medical Center, 9600 Leiden, The Netherlands.ORCID 0000-0002-4814-6426
Luis J CruzTranslational Nanobiomaterials and Imaging (TNI) Group, Radiology Department, Leiden University Medical Center, 9600 Leiden, The Netherlands.
Raimundo Fernandes de Araújo JuniorPostgraduate Program in Health Science, Federal University of Rio Grande do Norte (UFRN), Natal 59064-720, Brazil.ORCID 0000-0003-2349-2354

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.119850/2016-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.133518/2016-01H2020 Marie Skłodowska-Curie Actions 734684 (CHARMED)H2020 Marie Skłodowska-Curie Actions 777682 (CANCER)H2020 Marie Skłodowska-Curie Actions 852985 (SIMICA)H2020 Marie Skłodowska-Curie Actions 872391 (CONCRETE)H2020 Marie Skłodowska-Curie Actions 952520 (BIOSAFETY)H2020 Marie Skłodowska-Curie Actions ACORN (807281)H2020 Marie Skłodowska-Curie Actions PRISAR2 (872860)
6 · The paper itself

Abstract

Nanotechnology is a promising tool for the treatment of cancer. In the past decades, major steps have been made to bring nanotechnology into the clinic in the form of nanoparticle-based drug delivery systems. The great hope of drug delivery systems is to reduce the side effects of chemotherapeutics while simultaneously increasing the efficiency of the therapy. An increased treatment efficiency would greatly benefit the quality of life as well as the life expectancy of cancer patients. However, besides its many advantages, nanomedicines have to face several challenges and hurdles before they can be used for the effective treatment of tumors. Here, we give an overview of the hallmarks of cancer, especially colorectal cancer, and discuss biological barriers as well as how drug delivery systems can be utilized for the effective treatment of tumors and metastases.

Indexed as

biological barrierscancerdrug delivery systemnanomedicinenanoparticles

Identifiers

PMID34452282
PMCPMC8399070

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.