Evidence map›Paper›PMID 34452213›Full record

ArticlePharmaceutics2021

Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy.

Daniil V Gladkikh, Aleksandra V Sen Kova, Ivan V Chernikov, Tatyana O Kabilova, Nelly A Popova, Valery P Nikolin, Elena V Shmendel, Mikhail A Maslov, Valentin V Vlassov, Marina A Zenkova and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  8. A Novel 3-ACS omega · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Daniil V GladkikhInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.ORCID 0000-0003-3736-0803
Aleksandra V Sen KovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Ivan V ChernikovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Tatyana O KabilovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Nelly A PopovaThe Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Acad. Lavrentjev Avenue, 630090 Novosibirsk, Russia.
Valery P NikolinThe Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Acad. Lavrentjev Avenue, 630090 Novosibirsk, Russia.
Elena V ShmendelInstitute of Fine Chemical Technologies, MIREA, Russian Technological University, 119571 Moscow, Russia.ORCID 0000-0003-3727-4905
Mikhail A MaslovInstitute of Fine Chemical Technologies, MIREA, Russian Technological University, 119571 Moscow, Russia.ORCID 0000-0002-5372-1325
Valentin V VlassovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Marina A ZenkovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.ORCID 0000-0003-4044-1049
Elena L ChernolovskayaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Institute of Chemical Biology and Fundamental Medicine · RUInstitute of Cytology and Genetics · RUMIREA - Russian Technological University · RU

Funding

Russian Foundation for Basic Research 18-29-08009Russian Science Foundation 19-74-30011Russian State funded budget ICBFM N0245-2021-0005
6 · The paper itself

Abstract

In this study, we examined the in vivo toxicity of the liposomes F consisting of 1,26-bis(cholest-5-en-3-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride, lipid-helper 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine and folate lipoconjugate (

Indexed as

cationic liposomesfolate-containing lipoconjugatefolic acidMDR1 genesiRNAtargeted deliverytransfectionxenograft tumor model

Identifiers

PMID34452213
PMCPMC8399439
OpenAlexW3193405436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.