Evidence map›Paper›PMID 34452211›Full record

ArticlePharmaceutics2021

Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery.

José Antonio Lebrón, Manuel López-López, Clara B García-Calderón, Ivan V Rosado, Fernando R Balestra, Pablo Huertas, Roman V Rodik, Vitaly I Kalchenko, Eva Bernal, María Luisa Moyá and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Calix[4]arene Polyamine Triazoles: Synthesis, Aggregation and DNA Binding.International journal of molecular sciences · 2022
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

José Antonio LebrónDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain.ORCID 0000-0002-6938-3690
Manuel López-LópezDepartment of Chemical Engineering, Physical Chemistry and Materials Science, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, Avda. de las Fuerzas Armadas s/n, 21071 Huelva, Spain.ORCID 0000-0001-9060-9554
Clara B García-CalderónInstitute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Avda. Manuel Siurot s/n, 41013 Seville, Spain.
Ivan V RosadoInstitute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Avda. Manuel Siurot s/n, 41013 Seville, Spain.ORCID 0000-0001-7409-7341
Fernando R BalestraDepartment of Genetics, Faculty of Biology, University of Seville, C/Profesor García González 1, 41012 Seville, Spain.
Pablo HuertasDepartment of Genetics, Faculty of Biology, University of Seville, C/Profesor García González 1, 41012 Seville, Spain.ORCID 0000-0002-1756-4449
Roman V RodikInstitute of Organic Chemistry, National Academy of Science of Ukraine, Murmanska Str. 5, 02660 Kiev, Ukraine.
Vitaly I KalchenkoInstitute of Organic Chemistry, National Academy of Science of Ukraine, Murmanska Str. 5, 02660 Kiev, Ukraine.
Eva BernalDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain.
María Luisa MoyáDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain.ORCID 0000-0002-2736-9348
Pilar López-CornejoDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain.ORCID 0000-0002-5825-9483
Francisco J OstosDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain.ORCID 0000-0001-6583-6974
Universidad de Sevilla · ESCentro Andaluz de Biología Molecular y Medicina Regenerativa · ESInstituto de Biomedicina de Sevilla · ESNational Academy of Sciences of Ukraine · UAUniversidad de Huelva · ES

Funding

Consejería de Conocimiento, Innovación y Universidades 1042 de la Junta de Andalucía FQM-274Consejería de Conocimiento, Innovación y Universidades 1042 de la Junta de Andalucía PY20-01234Consejería de Conocimiento, Innovación y Universidades de la Junta de Andalucía FQM-206European Union Feder FundsFondo Social Europeo Fundación ONCESpanish Ministry of Science and Innovation-Agencia Estatal de Investigación PID2019-104195GUniversity of Seville VPPI-USVI Plan Propio Universidad de Sevilla P18-RT-1271VI Plan Propio Universidad de Sevilla PI18-0005-2018VI Plan Propio Universidad de Sevilla PP2019/00000748VI Plan Propio Universidad de Sevilla RTI2018-100692-B-100VI Plan Propio Universidad de Sevilla RYC-2015-18670VI Plan Propio Universidad de Sevilla VI-PP 1044 AY.SUPLEM-2019
6 · The paper itself

Abstract

The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried out using several techniques. Four amphiphilic calixarenes were used. The length of the hydrophobic chains attached to the lower rim as well as the nature of the polar group present in the upper rim of the calixarenes were varied. The lipid bilayer was formed with one calixarene and with the phospholipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE. The cytotoxicity of the liposomes for various cell lines was also studied. From the results obtained, the liposomes formed with the least cytotoxic calixarene, (TEAC

Indexed as

cationic calix[4]arenesdoxorubicinencapsulationliposomesnucleic acidstransfection efficiency

Identifiers

PMID34452211
PMCPMC8398082
OpenAlexW3191320483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.