Evidence map›Paper›PMID 34452207›Full record

ArticlePharmaceutics2021

Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics.

Yunqing Li, Marianna Inglese, Suraiya Dubash, Chris Barnes, Diana Brickute, Marta Costa Braga, Ning Wang, Alice Beckley, Kathrin Heinzmann, Louis Allott and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Bench to Bedside Development of [Molecules (Basel, Switzerland) · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Yunqing LiCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.ORCID 0000-0002-5378-4844
Marianna IngleseCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Suraiya DubashCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Chris BarnesCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Diana BrickuteCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Marta Costa BragaCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.ORCID 0000-0002-2673-776X
Ning WangCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Alice BeckleyCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Kathrin HeinzmannCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Louis AllottCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.ORCID 0000-0002-1025-0738
Haonan LuCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.ORCID 0000-0002-2472-7488
Cen ChenCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Ruisi FuCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Laurence CarrollCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.
Eric O AboagyeCancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2BX, UK.ORCID 0000-0003-2276-6771
Imperial College London · GBJohns Hopkins University · US

Funding

Cancer Research UK 16584Cancer Research UK C2536/A10337Medical Research Council MR/N020782/1
6 · The paper itself

Abstract

Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotracer [

Indexed as

choline kinaseeffluxhypoxia

Identifiers

PMID34452207
PMCPMC8400349
OpenAlexW3191315349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.