Evidence map›Paper›PMID 34452144›Full record

ArticlePharmaceutics2021

Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering and Stabilization of the Viruses.

Dhanik Reshamwala, Sailee Shroff, Olivier Sheik Amamuddy, Valentino Laquintana, Nunzio Denora, Antonella Zacheo, Vili Lampinen, Vesa P Hytonen, Özlem Tastan Bishop, Silke Krol and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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  11. Antiviral Mechanisms ofPharmaceutics · 2023
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  15. Willow (Frontiers in microbiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Dhanik ReshamwalaDepartment of Biological and Environmental Science/Nanoscience Center, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0002-0924-076X
Sailee ShroffDepartment of Biological and Environmental Science/Nanoscience Center, University of Jyväskylä, 40014 Jyväskylä, Finland.
Olivier Sheik AmamuddyResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-1781-1382
Valentino LaquintanaDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Morro", 70125 Bari, Italy.ORCID 0000-0003-1266-638X
Nunzio DenoraDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Morro", 70125 Bari, Italy.ORCID 0000-0002-7756-7828
Antonella ZacheoLaboratory for Nanotechnology, IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
Vili LampinenFaculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.ORCID 0000-0003-2153-6149
Vesa P HytonenFaculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.ORCID 0000-0002-9357-1480
Özlem Tastan BishopResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0001-6861-7849
Silke KrolLaboratory for Personalized Medicine, National Institute of Gastroenterology, "S. de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.ORCID 0000-0003-3108-9821
Varpu MarjomäkiDepartment of Biological and Environmental Science/Nanoscience Center, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0002-4592-5926
University of Jyväskylä · FIRhodes University · ZATampere University · FIUniversity of Bari Aldo Moro · ITGastroenterology Hospital "Saverio de Bellis" · ITIstituto Tumori Bari · IT

Funding

Jane ja Aatos Erkon Säätiö not available
6 · The paper itself

Abstract

To efficiently lower virus infectivity and combat virus epidemics or pandemics, it is important to discover broadly acting antivirals. Here, we investigated two naturally occurring polyphenols, Epigallocatechin gallate (EGCG) and Resveratrol (RES), and polyphenol-functionalized nanoparticles for their antiviral efficacy. Concentrations in the low micromolar range permanently inhibited the infectivity of high doses of enteroviruses (10

Indexed as

antiviral efficacyenterovirusesfunctionalized gold nanoparticlespolyphenolsstabilization

Identifiers

PMID34452144
PMCPMC8398301
OpenAlexW3187884630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.