Evidence map›Paper›PMID 34452075›Full record

ArticlePharmaceutics2021

Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations.

Janine Boniatti, Patricija Januskaite, Laís B da Fonseca, Alessandra L Viçosa, Fábio C Amendoeira, Catherine Tuleu, Abdul W Basit, Alvaro Goyanes, Maria-Inês Ré

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 78 citations in OpenAlex.

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  15. A case study on decentralized manufacturing of 3D printed medicines.International journal of pharmaceutics: X · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Janine BoniattiIMT Mines Albi-Carmaux, CNRS UMR 5302, Centre RAPSODEE, Campus Jarlard, Université de Toulouse, CEDEX 09, 81013 Albi, France.
Patricija JanuskaiteDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0001-5717-6400
Laís B da FonsecaOswaldo Cruz Foundation, Rua Sizenando Nabuco, 100 CEP 22.775-903, Rio de Janeiro 21040-900, Brazil.
Alessandra L ViçosaOswaldo Cruz Foundation, Rua Sizenando Nabuco, 100 CEP 22.775-903, Rio de Janeiro 21040-900, Brazil.
Fábio C AmendoeiraOswaldo Cruz Foundation, Rua Sizenando Nabuco, 100 CEP 22.775-903, Rio de Janeiro 21040-900, Brazil.
Catherine TuleuDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0001-8384-357X
Abdul W BasitDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0002-5368-6603
Alvaro GoyanesDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0002-3378-6797
Maria-Inês RéIMT Mines Albi-Carmaux, CNRS UMR 5302, Centre RAPSODEE, Campus Jarlard, Université de Toulouse, CEDEX 09, 81013 Albi, France.
Fundação Oswaldo Cruz · BRUniversity College London · GBCentre National de la Recherche Scientifique · FRUniversidade de Santiago de Compostela · ES

Funding

Engineering and Physical Sciences Research Council EP/S023054/1Fundação Oswaldo Cruz VPPIS-001-FIO-18-41
6 · The paper itself

Abstract

For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide. However, there is no suitable paediatric formulation on the market, leading to off-label use and the splitting of commercial tablets for adults. In this study, we use a recently available technology, direct powder extrusion (DPE) three-dimensional printing (3DP), to prepare paediatric Printlets™ (3D printed tablets) of amorphous solid dispersions of praziquantel with Kollidon

Indexed as

3D printed drug products3D printingM3DIMAKER printermaterial extrusion additive manufacturingoral drug delivery systems and technologiespediatric treatmentspersonalized therapeuticsprinting pharmaceuticals and medicinestaste maskingtranslational pharmaceutics

Identifiers

PMID34452075
PMCPMC8398999
OpenAlexW3185666545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.