Evidence map›Paper›PMID 34452033›Full record

ArticleVaccines2021

Tick-Borne Encephalitis Specific Lymphocyte Response after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Humoral Immunity after Vaccination.

Nicole Harrison, Katharina Grabmeier-Pfistershammer, Alexandra Graf, Doris Trapin, Peter Tauber, Judith H Aberle, Karin Stiasny, Ralf Schmidt, Hildegard Greinix, Werner Rabitsch and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01991067 (Characterization of Humoral and Cellular Immunity for Tick-borne Encephalitis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01991067 phase2completednot on this map

Characterization of Humoral and Cellular Immunity for Tick-borne Encephalitis (TBE) Vaccination in Allogeneic Blood and Marrow Graft Recipients: a Pilot Study

TypeinterventionalSponsorMedical University of ViennaRan2014 to 2018Enrolled34ConditionsTick Borne EncephalitisArmsTBE virus vaccine
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The frequency of differentiated CD3Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Nicole HarrisonDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5971-0662
Katharina Grabmeier-PfistershammerDivision of Cellular Immunology and Immunohematology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Alexandra GrafSection of Medical Statistics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, 1090 Vienna, Austria.
Doris TrapinDivision of Cellular Immunology and Immunohematology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Peter TauberDivision of Cellular Immunology and Immunohematology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Judith H AberleCenter for Virology, Medical University of Vienna, 1090 Vienna, Austria.
Karin StiasnyCenter for Virology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-1902-8674
Ralf SchmidtDivision of Virology, Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Hildegard GreinixDivision of Hematology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Werner RabitschBone Marrow Transplantation Unit, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Michael RamharterDepartment of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20359 Hamburg, Germany.ORCID 0000-0002-9259-1885
Heinz BurgmannDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Winfried F PicklDivision of Cellular Immunology and Immunohematology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Christina BahrsDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-4427-2839
Medical University of Vienna · ATJena University Hospital · DEMedical University of Graz · ATStatistics Austria · ATUniversität Hamburg · DE

Funding

Austrian Science Fund grant number KLI 372
6 · The paper itself

Abstract

The aim of this prospective study was to assess lymphocyte proliferative and cytokine response prior to and following tick-borne encephalitis (TBE) immunization among patients after allogeneic hematopoietic stem cell transplantation (HSCT). Seventeen adult patients 11-13 months after HSCT and eight unvaccinated healthy adults received up to three TBE vaccinations. Following in vitro stimulation with TBE-antigen, lymphocyte proliferation and cytokine secretion (IL-2, IL-10, IL-13, TNF-alpha, IFN-gamma, GM-CSF) were analyzed by thymidine incorporation assay and the Luminex system. Ten patients (59%) showed significant baseline TBE-specific lymphocyte proliferation (stimulation index (SI) > 3) prior to vaccination, but none of the unvaccinated controls (

Indexed as

allogeneic stem cell transplantcytokine responsehumoral respondersinterleukin 13lymphocyte proliferationsibling donorstick-borne encephalitis vaccination

Identifiers

PMID34452033
PMCPMC8402406
OpenAlexW3194359666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.