Evidence map›Paper›PMID 34452006›Full record

ArticleVaccines2021

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge.

R Glenn King, Aaron Silva-Sanchez, Jessica N Peel, Davide Botta, Alexandria M Dickson, Amelia K Pinto, Selene Meza-Perez, S Rameeza Allie, Michael D Schultz, Mingyong Liu and 26 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 124 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 3 institutions in 1 country.

R Glenn KingDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-6522-0053
Aaron Silva-SanchezDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jessica N PeelDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Davide BottaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-3926-0662
Alexandria M DicksonDepartment of Molecular Microbiology & Immunology, Saint Louis University, St. Louis, MO 63104, USA.
Amelia K PintoDepartment of Molecular Microbiology & Immunology, Saint Louis University, St. Louis, MO 63104, USA.ORCID 0000-0002-7147-3978
Selene Meza-PerezDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
S Rameeza AllieDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Michael D SchultzDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-6741-4115
Mingyong LiuDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
John E BradleyDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Shihong QiuDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Guang YangDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Fen ZhouDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Esther ZumaqueroDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Thomas S SimplerDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Betty MousseauDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
John T KillianDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Brittany DeanDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Qiao ShangDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jennifer L TipperDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Christopher A RisleyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-6527-1077
Kevin S HarrodDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-0780-9470
Tsungwei FengAltimmune Inc., Gaithersburg, MD 20878, USA.
Young LeeAltimmune Inc., Gaithersburg, MD 20878, USA.
Bethlehem ShiberuAltimmune Inc., Gaithersburg, MD 20878, USA.
Vyjayanthi KrishnanAltimmune Inc., Gaithersburg, MD 20878, USA.
Isabelle PeguilletAltimmune Inc., Gaithersburg, MD 20878, USA.
Jianfeng ZhangAltimmune Inc., Gaithersburg, MD 20878, USA.
Todd J GreenDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-1158-4710
Troy D RandallDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
John J SuschakAltimmune Inc., Gaithersburg, MD 20878, USA.ORCID 0000-0002-2867-8265
Bertrand GeorgesAltimmune Inc., Gaithersburg, MD 20878, USA.
James D BrienDepartment of Molecular Microbiology & Immunology, Saint Louis University, St. Louis, MO 63104, USA.ORCID 0000-0002-1670-8041
Frances E LundDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
M Scot RobertsAltimmune Inc., Gaithersburg, MD 20878, USA.
University of Alabama at Birmingham · USAltimmune (United States) · USSaint Louis University · US

Funding

Tissue and organ specific human B cell immunity: Supplement - Metabolic Risk Factors and Inflammation in PASC DevelopmentU19AI142737 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROSENBERG, ALEXANDER · 2019 to 2023
$19.7M
Molecular Analysis and Lineage Tracing of Influenza-Specific, Lung-Resident Memory B CellsR01AI152476 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2020 to 2025
$5.5M
NIAID NIH HHS R01 AI152476NIAID NIH HHS U19 AI142737NIH HHS 1U01CA260541-01NIH HHS 3U19AI142737
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Intranasal vaccination is an attractive strategy to prevent COVID-19 as the nasal mucosa represents the first-line barrier to SARS-CoV-2 entry. The current intramuscular vaccines elicit systemic immunity but not necessarily high-level mucosal immunity. Here, we tested a single intranasal dose of our candidate adenovirus type 5-vectored vaccine encoding the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (AdCOVID) in inbred, outbred, and transgenic mice. A single intranasal vaccination with AdCOVID elicited a strong and focused immune response against RBD through the induction of mucosal IgA in the respiratory tract, serum neutralizing antibodies, and CD4

Indexed as

adenovirus vectorCOVID-19IgAintranasalmucosal immunityreceptor binding domainSARS-CoV-2vaccineviral vector

Identifiers

PMID34452006
PMCPMC8402488
OpenAlexW3187526644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.