Evidence map›Paper›PMID 34451921›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Gene Polymorphisms of the Renin-Angiotensin System and Bleeding Complications of Warfarin: Genetic-Based Machine Learning Models.

Joo-Hee Kim, Jeong Yee, Byung-Chul Chang, Hye-Sun Gwak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Artificial intelligence in clinical thrombosis and hemostasis: A review.Research and practice in thrombosis and haemostasis · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Joo-Hee KimInstitute of Pharmaceutical Science and Technology, College of Pharmacy, Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea.ORCID 0000-0003-3458-0528
Jeong YeeGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea.
Byung-Chul ChangBundang CHA Medical Center, Department of Thoracic and Cardiovascular Surgery, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Korea.
Hye-Sun GwakGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea.ORCID 0000-0003-0278-2563
Ewha Womans University · KRAjou University · KRYonsei University · KR

Funding

National Research Foundation of Korea 2017R1D1A1B03034033
6 · The paper itself

Abstract

backgroundThis study aimed to investigate the effects of genetic variants and haplotypes in the renin-angiotensin system (RAS) on the risk of warfarin-induced bleeding complications at therapeutic international normalized ratios (INRs).

methodsFour single nucleotide polymorphisms (SNPs) of

resultsThe study included 142 patients, among whom 21 experienced bleeding complications. We identified a haplotype, H2 (TCG), carrying three SNPs of

conclusionThis study demonstrated that RAS-related polymorphisms, including the H2 haplotype of the

Indexed as

haplotypehemorrhagemachine learningpolymorphismrenin–angiotensin systemwarfarin

Identifiers

PMID34451921
PMCPMC8400908
OpenAlexW3195319933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.