Evidence map›Paper›PMID 34451906›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

A High-Content Screen for the Identification of Plant Extracts with Insulin Secretion-Modulating Activity.

Roland Hager, Johannes Pitsch, Jakob Kerbl-Knapp, Cathrina Neuhauser, Nicole Ollinger, Marcus Iken, Josef Ranner, Verena Mittermeier-Kleßinger, Corinna Dawid, Peter Lanzerstorfer and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Therapeutic Potentials of Jamun (International journal of food science · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Enhancement of nutraceutical and anti-diabetic potential of fenugreek (Trigonella foenum-graecum). Sprouts with natural elicitors.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Small-molecule discovery in the pancreatic beta cell.Current opinion in chemical biology · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Roland HagerSchool of Engineering, University of Applied Sciences Upper Austria, 4600 Wels, Austria.ORCID 0000-0003-3389-3186
Johannes PitschSchool of Engineering, University of Applied Sciences Upper Austria, 4600 Wels, Austria.ORCID 0000-0002-9393-9062
Jakob Kerbl-KnappSchool of Engineering, University of Applied Sciences Upper Austria, 4600 Wels, Austria.
Cathrina NeuhauserSchool of Engineering, University of Applied Sciences Upper Austria, 4600 Wels, Austria.
Nicole OllingerFFoQSI-Austrian Competence Center for Feed and Food Quality, 3430 Tulln, Austria.ORCID 0000-0003-2659-6968
Marcus IkenPM International AG, 5445 Schengen, Luxembourg.
Josef RannerFood Chemistry and Molecular Sensory Science, Technical University of Munich, 85354 Freising, Germany.
Verena Mittermeier-KleßingerFood Chemistry and Molecular Sensory Science, Technical University of Munich, 85354 Freising, Germany.ORCID 0000-0003-3697-1151
Corinna DawidFood Chemistry and Molecular Sensory Science, Technical University of Munich, 85354 Freising, Germany.ORCID 0000-0001-5342-2600
Peter LanzerstorferSchool of Engineering, University of Applied Sciences Upper Austria, 4600 Wels, Austria.ORCID 0000-0003-4512-7964
Julian WeghuberSchool of Engineering, University of Applied Sciences Upper Austria, 4600 Wels, Austria.ORCID 0000-0001-6312-4666
University of Applied Sciences Upper Austria · ATLeibniz-Institute for Food Systems Biology at the Technical University of Munich · DEINTRASOFT International (Luxembourg) · LU

Funding

Christian Doppler Forschungsgesellschaft Josef Ressel Center for Phytogenic Drug Research
6 · The paper itself

Abstract

Bioactive plant compounds and extracts are of special interest for the development of pharmaceuticals. Here, we describe the screening of more than 1100 aqueous plant extracts and synthetic reference compounds for their ability to stimulate or inhibit insulin secretion. To quantify insulin secretion in living MIN6 β cells, an insulin-

Indexed as

bioactivesdiabetesGC-MSinsulinLC-MSluciferasenatural compoundsnatural plant extractsscreeningWestern blottingβ cells

Identifiers

PMID34451906
PMCPMC8402219
OpenAlexW3195651404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.