Evidence map›Paper›PMID 34451867›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds.

Hamza Mechchate, Regiane Costa de Oliveira, Imane Es-Safi, Emmily Myrella Vasconcelos Mourão, Mohamed Bouhrim, Andrii Kyrylchuk, Gemilson Soares Pontes, Dalila Bousta, Andriy Grafov

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Molecules (Basel, Switzerland) · 2023
    Review
  9. Coriander (Molecules (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Article
  12. Efficiency ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  13. Article
  14. Molecules (Basel, Switzerland) · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Hamza MechchateLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA), Fez B.P. 1796, Morocco.ORCID 0000-0003-4571-9089
Regiane Costa de OliveiraPost-Graduate Program in Haematology, School of Health Sciences, University of the State of Amazonas, Av. Djalma Batista 3578, Manaus 69050-010, AM, Brazil.ORCID 0000-0003-0319-785X
Imane Es-SafiLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA), Fez B.P. 1796, Morocco.ORCID 0000-0002-9239-3045
Emmily Myrella Vasconcelos MourãoLaboratory of Virology, National Institute of Amazonian Research (INPA), Av. André Araújo 2.936, Petrópolis, Manaus 69067-375, AM, Brazil.ORCID 0000-0003-4502-9168
Mohamed BouhrimLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda B.P. 717, Morocco.
Andrii KyrylchukInstitute of Organic Chemistry, National Academy of Sciences, Murmanska Str. 5, 02660 Kyiv, Ukraine.ORCID 0000-0002-8845-5194
Gemilson Soares PontesPost-Graduate Program in Haematology, School of Health Sciences, University of the State of Amazonas, Av. Djalma Batista 3578, Manaus 69050-010, AM, Brazil.ORCID 0000-0001-9001-7954
Dalila BoustaLaboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA), Fez B.P. 1796, Morocco.
Andriy GrafovDepartment of Chemistry, University of Helsinki, A.I. Virtasen aukio 1, 00560 Helsinki, Finland.ORCID 0000-0002-7387-3676
Sidi Mohamed Ben Abdellah University · MAInstituto Nacional de Pesquisas da Amazônia · BRInstitute of Organic Chemistry · UAMohamed I University · MAUniversidade do Estado do Amazonas · BRUniversity of Helsinki · FI

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil PROCAD AMAZÔNIA 88881.200581/201801Horizon 2020 Framework Programme MSCA-RISE-2016-734759, acronym VAHVISTUS
6 · The paper itself

Abstract

Leukemia is a group of hematological neoplastic disorders linked to high mortality rates worldwide, but increasing resistance has led to the therapeutic failure of conventional chemotherapy. This study aimed to evaluate in vitro the antileukemic activity and potential mechanism of action of a polyphenolic extract obtained from the seeds of

Indexed as

ABL1ABL kinaseacute toxicityanticancer activityBCL2Coriandrum sativum L.FLT3HL60K562leukemiamolecular dockingOECD 423polyphenolsVero cell line

Identifiers

PMID34451867
PMCPMC8400422
OpenAlexW3188854984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.