Evidence map›Paper›PMID 34451840›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

A Novel Cardenolide Glycoside Isolated from

Anuradha Thakur, Phanankosi Moyo, Carl Johan van der Westhuizen, Hyun Ok Yang, Vinesh Maharaj

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Anuradha ThakurDepartment of Chemistry, University of Pretoria, Pretoria 0028, South Africa.
Phanankosi MoyoDepartment of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria 0028, South Africa.ORCID 0000-0001-7692-3256
Carl Johan van der WesthuizenFuture Production: Chemicals, Council for Scientific and Industrial Research (CSIR), Meiring Naudé Road, Pretoria 0001, South Africa.ORCID 0000-0002-6377-9280
Hyun Ok YangNatural Products Research Centre, Korea Institute of Science and Technology, Gangneung 25451, Gangwon-Do, Korea.
Vinesh MaharajDepartment of Chemistry, University of Pretoria, Pretoria 0028, South Africa.
University of Pretoria · ZACouncil for Scientific and Industrial Research · ZASejong University · KR

Funding

Bio & Medical Technology Development Program NRF-2015M3A9A5030735
6 · The paper itself

Abstract

Elevated levels of the amylo β-proteins (Aβ), particularly Aβ42, are associated with a high risk of Alzheimer's disease (AD). The Aβ proteins are produced from cellular processing of the amyloid precursor proteins (APPs). To identify natural products that block the formation of Aβ-proteins from APPs, we previously screened a library of plant extracts and identified

Indexed as

acetylated glycosydated crotoxigeninAlzheimerAβ42 reductionnatural productsnuclear magnetic resonance (NMR)Xysmalobium undulatumxysmalogenin-3β-d-glucopyranoside

Identifiers

PMID34451840
PMCPMC8400651
OpenAlexW3185235264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.