Evidence map›Paper›PMID 34451800›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Engineered EVs for Oxidative Stress Protection.

Anna Maria Tolomeo, Santina Quarta, Alessandra Biasiolo, Mariagrazia Ruvoletto, Michela Pozzobon, Giada De Lazzari, Ricardo Malvicini, Cristian Turato, Giorgio Arrigoni, Patrizia Pontisso and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Anna Maria TolomeoDepartment of Women's and Children's Health, University of Padova, Via Giustiniani, 35128 Padova, Italy.
Santina QuartaL.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani, 35128 Padova, Italy.ORCID 0000-0002-9348-1485
Alessandra BiasioloL.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani, 35128 Padova, Italy.
Mariagrazia RuvolettoL.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani, 35128 Padova, Italy.
Michela PozzobonDepartment of Women's and Children's Health, University of Padova, Via Giustiniani, 35128 Padova, Italy.ORCID 0000-0001-9213-402X
Giada De LazzariDepartment of Women's and Children's Health, University of Padova, Via Giustiniani, 35128 Padova, Italy.ORCID 0000-0002-5217-8201
Ricardo MalviciniDepartment of Women's and Children's Health, University of Padova, Via Giustiniani, 35128 Padova, Italy.ORCID 0000-0002-2764-6165
Cristian TuratoDepartment of Molecular Medicine, University of Pavia, 9 Via A Ferrata, 27100 Pavia, Italy.ORCID 0000-0001-7086-0792
Giorgio ArrigoniDepartment of Biomedical Sciences, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-4103-2733
Patrizia PontissoL.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via Giustiniani, 35128 Padova, Italy.
Maurizio MuracaDepartment of Women's and Children's Health, University of Padova, Via Giustiniani, 35128 Padova, Italy.
University of Padua · ITUniversity of Pavia · IT

Funding

CORIS Regione Veneto, Italy No grant number
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are increasingly studied as vectors for drug delivery because they can transfer a variety of molecules across biological barriers. SerpinB3 is a serine protease inhibitor that has shown a protective anti-apoptotic function in a variety of stressful conditions. The aim of this study was to evaluate protection from oxidative stress-induced damage, using extracellular vesicles that overexpress SerpinB3 (EVs-SB3) in order to enhance the effect of extracellular vesicles on cellular homeostasis. EVs-SB3s were obtained from HepG2 cells engineered to overexpress SerpinB3 and they revealed significant proteomic changes, mostly characterized by a reduced expression of other proteins compared with EVs from non-engineered cells. These EV preparations showed a significantly higher protection from H

Indexed as

cytoprotectionextracellular vesiclesoxidative stressSerpinB3

Identifiers

PMID34451800
PMCPMC8399368
OpenAlexW3186424584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.