Evidence map›Paper›PMID 34451527›Full record

ArticlePathogens (Basel, Switzerland)2021

Gut Microbiota in Military International Travelers with Doxycycline Malaria Prophylaxis: Towards the Risk of a Simpson Paradox in the Human Microbiome Field.

Emilie Javelle, Aurélie Mayet, Matthieu Million, Anthony Levasseur, Rodrigue S Allodji, Catherine Marimoutou, Chrystel Lavagna, Jérôme Desplans, Pierre Edouard Fournier, Didier Raoult and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Emilie JavelleLaveran Military Teaching Hospital, Boulevard Alphonse Laveran, 13013 Marseille, France.
Aurélie MayetCentre d'Epidémiologie et de Santé Publique des Armées (CESPA), 13014 Marseille, France.
Matthieu MillionIHU-Méditerranée Infection, 19-21 Boulevard Alphonse Laveran, 13013 Marseille, France.
Anthony LevasseurIHU-Méditerranée Infection, 19-21 Boulevard Alphonse Laveran, 13013 Marseille, France.
Rodrigue S AllodjiRadiation Epidemiology Team, CESP, Inserm U1018, 94800 Villejuif, France.ORCID 0000-0002-1895-8415
Catherine MarimoutouCentre d'Epidémiologie et de Santé Publique des Armées (CESPA), 13014 Marseille, France.
Chrystel LavagnaCentre d'Epidémiologie et de Santé Publique des Armées (CESPA), 13014 Marseille, France.
Jérôme DesplansCentre d'Epidémiologie et de Santé Publique des Armées (CESPA), 13014 Marseille, France.
Pierre Edouard FournierIRD, AP-HM, SSA, VITROME, Aix Marseille University, 13000 Marseille, France.
Didier RaoultIHU-Méditerranée Infection, 19-21 Boulevard Alphonse Laveran, 13013 Marseille, France.
Gaëtan TexierIRD, AP-HM, SSA, VITROME, Aix Marseille University, 13000 Marseille, France.
Aix-Marseille Université · FRInserm · FRSanté Publique France · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysbiosis, developed upon antibiotic administration, results in loss of diversity and shifts in the abundance of gut microbes. Doxycycline is a tetracycline antibiotic widely used for malaria prophylaxis in travelers. We prospectively studied changes in the fecal microbiota of 15 French soldiers after a 4-month mission to Mali with doxycycline malaria prophylaxis, compared to changes in the microbiota of 28 soldiers deployed to Iraq and Lebanon without doxycycline. Stool samples were collected with clinical data before and after missions, and 16S rRNA sequenced on MiSeq targeting the V3-V4 region. Doxycycline exposure resulted in increased alpha-biodiversity and no significant beta-dissimilarities. It led to expansion in

Indexed as

Bacteroidesdeploymentdoxycyclinegroup-effectgut microbiotamalaria prophylaxismissionRothiaSimpson paradoxsoldierstetracyclinetravel

Identifiers

PMID34451527
PMCPMC8400693
OpenAlexW3195604391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.