Evidence map›Paper›PMID 34451494›Full record

ReviewPathogens (Basel, Switzerland)2021

An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era.

Alejandro Pascual-Iglesias, Javier Canton, Ana Maria Ortega-Prieto, Jose M Jimenez-Guardeño, Jose Angel Regla-Nava

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025
    Review
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  12. Article
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  16. High viral loads: what drives fatal cases of COVID-19 in vaccinees? - an autopsy study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Alejandro Pascual-IglesiasThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.ORCID 0000-0002-2214-5441
Javier CantonInternational Institute for Defense and Security (CISDE), 41007 Sevilla, Spain.ORCID 0000-0002-0324-9384
Ana Maria Ortega-PrietoDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK.ORCID 0000-0002-9023-0103
Jose M Jimenez-GuardeñoDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK.
Jose Angel Regla-NavaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
King's College London · GBLa Jolla Institute for Immunology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants.

Indexed as

clinical trialcoronavirusCOVID-19pandemicSARS-CoV-2vaccine

Identifiers

PMID34451494
PMCPMC8402174
OpenAlexW3194227053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.