Evidence map›Paper›PMID 34451492›Full record

ArticlePathogens (Basel, Switzerland)2021

Limited HIV-1 Subtype C

Kaelo K Seatla, Dorcas Maruapula, Wonderful T Choga, Olorato Morerinyane, Shahin Lockman, Vladimir Novitsky, Ishmael Kasvosve, Sikhulile Moyo, Simani Gaseitsiwe

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01965470 (Botswana Combination Prevention Project), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01965470 phase4completednot on this map

Botswana Combination Prevention Project: -Evaluation Protocol (Protocol #1): Research Design and Impact Evaluation -Closed Clinical Cohort Protocol (Protocol #3) Implementation, Monitoring and Evaluation of Combination HIV Prevention Interventions in Rural and Peri-Urban Communities in Botswana

TypeinterventionalSponsorCenters for Disease Control and PreventionRan2013 to 2018ConditionsHIVArmsCombination Prevention, Enhanced Care
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Kaelo K SeatlaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Dorcas MaruapulaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Wonderful T ChogaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.ORCID 0000-0001-7606-0569
Olorato MorerinyaneBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Shahin LockmanBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Vladimir NovitskyThe Warren Alpert Medical School of Brown University, Providence, RI 12321, USA.
Ishmael KasvosveFaculty of Health Sciences, School of Allied Health Professions, University of Botswana, Gaborone, Botswana.ORCID 0000-0002-2046-545X
Sikhulile MoyoBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.ORCID 0000-0003-3821-4592
Simani GaseitsiweBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Harvard University · USUniversity of Botswana · BWBotswana Harvard AIDS Institute Partnership · BWProvidence College · USUniversity of Cape Town · ZA

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
Training in HIV Genomics, Treatment, and Cure Research in BotswanaD43TW009610 · FIC · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2013 to 2026
$4.4M
Mentoring in Patient-Oriented HIV Research in the Era of Universal ARTK24AI131928 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAHIN LOCKMAN · 2017 to 2026
$1.9M
CGH CDC HHS U01 GH000447CGH CDC HHS U2G GH001911FIC NIH HHS D43 TW009610FIC NIH HHS D43TW010543NIAID NIH HHS K24 AI131928NIAID NIH HHS P30 AI060354NIH HHS NIH K24 AI131928Wellcome Trust DEL-15-006
6 · The paper itself

Abstract

Dolutegravir (DTG) is a potent anti-HIV drug that is used to treat HIV globally. There have been reports of mutations in the HIV-1 3'-polypurine tract (3'PPT) of the

Indexed as

3′-polypurine tractBotswanadolutegravirdrug resistance mutationsHIV-1nef

Identifiers

PMID34451492
PMCPMC8400509
OpenAlexW3194982566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.