Evidence map›Paper›PMID 34451427›Full record

ArticlePathogens (Basel, Switzerland)2021

Impact of Cytomegalovirus Infection and Genetic Background on the Frequencies of Peripheral Blood Suppressor Cells in Human Twins.

David Goldeck, Lisbeth Aagaard Larsen, Kaare Christensen, Klaus Hamprecht, Lilly Öttinger, Karin Hähnel, Graham Pawelec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David GoldeckIndependent Researcher, Kidlington OX5 2PB, UK.
Lisbeth Aagaard LarsenThe Danish Twin Registry, University of Southern Denmark, 5000 Odense C, Denmark.
Kaare ChristensenThe Danish Twin Registry, University of Southern Denmark, 5000 Odense C, Denmark.
Klaus HamprechtInstitute of Medical Virology, University of Tübingen, D-72072 Tübingen, Germany.ORCID 0000-0003-4991-0155
Lilly ÖttingerDepartment of Psychiatry and Psychotherapy, Section for Dementia Research, University of Tübingen, D-72072 Tübingen, Germany.
Karin HähnelDepartment of Internal Medicine II, University Hospital Tübingen, D-72072 Tübingen, Germany.
Graham PawelecDepartment of Immunology, University of Tübingen, D-72072 Tübingen, Germany.ORCID 0000-0002-3600-0163

Funding

European Commission FP7 259679
6 · The paper itself

Abstract

Frequencies and proportions of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in peripheral blood may be informative biomarkers for certain disease states. The influence of genetics and lifetime pathogen exposures on Treg and MDSC frequencies is largely unexplored. Cytomegalovirus (CMV) establishes a latent infection and causes an accumulation of late-differentiated CD8+ memory T cells, commonly associated with a lower frequency of naive cells. Here, analyzing peripheral blood mononuclear cells by multicolor flow cytometry, we found a tendency towards lower frequencies of CD4+CD25+FoxP3+ Tregs in CMV-seropositive than -seronegative middle-aged individuals (

Indexed as

cytomegalovirusgeneticsheritabilitymyeloid-derived suppressor cellsregulatory T cellstwins

Identifiers

PMID34451427
PMCPMC8399020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.