Evidence map›Paper›PMID 34451207›Full record

ReviewPolymers2021

Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review.

Muhammad Al Rizqi Dharma Fauzi, Pratiwi Pudjiastuti, Arief Cahyo Wibowo, Esti Hendradi

Abstract readReview
In one paragraph

Review in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Article
  3. Marine drugs · 2025
    Article
  4. Article
  5. Synthesis and Characterization of Sodium Carboxymethylcellulose fromTurkish journal of pharmaceutical sciences · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Muhammad Al Rizqi Dharma FauziDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0003-2325-0267
Pratiwi PudjiastutiDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia.
Arief Cahyo WibowoFaculty of Advanced Technology and Multidiscipline, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0002-2454-4307
Esti HendradiDepartment of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.

Funding

Ministry of Education and Culture of Republic of Indonesia PMDSU Scholarship Program (2018-2021)
6 · The paper itself

Abstract

Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or eliminated for future use in drug-delivery systems. This review attempts to review the preparation and potential of seaweed-based, specifically carrageenan, hard capsules, summarise their properties and highlight their potential as an optional main component of hard capsules in a drug-delivery system. The characterisation methods reviewed were dimensional analysis, water and ash content, microbial activity, viscosity analysis, mechanical analysis, scanning electron microscopy, swelling degree analysis, gel permeation chromatography, Fourier-transform infrared spectroscopy and thermal analysis. The release kinetics of the capsule is highlighted as well. This review is expected to provide insights for new researchers developing innovative products from carrageenan-based hard capsules, which will support the development goals of the industry.

Indexed as

carrageenandrug-delivery systemhard capsuleproduct innovationseaweed

Identifiers

PMID34451207
PMCPMC8400433

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.