Evidence map›Paper›PMID 34451205›Full record

ArticlePolymers2021

Targeted Gold Nanohybrids Functionalized with Folate-Hydrophobic-Quaternized Pullulan Delivering Camptothecin for Enhancing Hydrophobic Anticancer Drug Efficacy.

Sakchai Laksee, Chamaiporn Supachettapun, Nongnuj Muangsin, Pattra Lertsarawut, Thitirat Rattanawongwiboon, Phitchan Sricharoen, Nunticha Limchoowong, Threeraphat Chutimasakul, Tanagorn Kwamman, Kasinee Hemvichian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sakchai LakseeNuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok 26120, Thailand.
Chamaiporn SupachettapunProgram in Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Nongnuj MuangsinDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Pattra LertsarawutNuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok 26120, Thailand.ORCID 0000-0001-5727-7703
Thitirat RattanawongwiboonNuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok 26120, Thailand.
Phitchan SricharoenNuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok 26120, Thailand.
Nunticha LimchoowongDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
Threeraphat ChutimasakulNuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok 26120, Thailand.
Tanagorn KwammanNuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok 26120, Thailand.ORCID 0000-0003-2377-8969
Kasinee HemvichianNuclear Technology Research and Development Center, Thailand Institute of Nuclear Technology (Public Organization), Nakhon Nayok 26120, Thailand.ORCID 0000-0002-6919-0290

Funding

Office of the Permanent Secretary, The Ministry of Higher Education, Science, Research and In-novation, Thailand A Program for Capacity-Building and Strategic Cooperation on Bilateral and Multilateral Basis Development (Thawiphaki-Pahuphaki 2564).Thailand Institute of Nuclear Technology (Public Organization), Thailand TINT to University
6 · The paper itself

Abstract

This study presented a green, facile and efficient approach for a new combination of targeted gold nanohybrids functionalized with folate-hydrophobic-quaternized pullulan delivering hydrophobic camptothecin (CPT-GNHs@FHQ-PUL) to enhance the efficacy, selectivity, and safety of these systems. New formulations of spherical CPT-GNHs@FHQ-PUL obtained by bio-inspired strategy were fully characterized by TEM, EDS, DLS, zeta-potential, UV-vis, XRD, and ATR-FTIR analyses, showing a homogeneous particles size with an average size of approximately 10.97 ± 2.29 nm. CPT was successfully loaded on multifunctional GNHs@FHQ-PUL via intermolecular interactions. Moreover, pH-responsive CPT release from newly formulated-CPT-GNHs@FHQ-PUL exhibited a faster release rate under acidic conditions. The intelligent CPT-GNHs@FHQ-PUL (IC

Indexed as

apoptosiscamptothecincytotoxicitydrug releasegold nanohybridshydrophobic anticancer drugintermolecular interactionsnanocarrierspullulan

Identifiers

PMID34451205
PMCPMC8400492

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.