ArticlePolymers2021
Characterization of Thermoresponsive Poly-N-Vinylcaprolactam Polymers for Biological Applications.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Development of poly(vinyl alcohol)/poly(N-vinyl caprolactam)-based hydrogel-forming microneedle for transdermal delivery of captopril: fabrication, characterization and in vivo antihypertensive activity test.Drug delivery and translational research · 2026Article
- Magnetothermally Responsive Mesoporous Silica Nanocarriers: Materials Design, Thermoresponsive Gates and Controlled Drug Release.Nanomaterials (Basel, Switzerland) · 2026Review
- A comprehensive review on thermo-responsive targeted and functional therapy for management of rheumatoid arthritis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Synthesis of a Stimulus-Sensitive Copolymer with Response to Temperature and pH in Silicone Catheters.Polymers · 2025Article
- Effect of SiOACS omega · 2025Article
- Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing.International journal of molecular sciences · 2025Article
- Smart Stimuli-responsive Nanogels: A Potential Tool for Targeted Drug Delivery.Current pharmaceutical design · 2025Review
- Enhancement of the Sensing Performance of Devices based on Multistimuli-Responsive Hybrid Materials.ACS applied materials & interfaces · 2024Review
- In Vitro Biological Evaluation of an Alginate-Based Hydrogel Loaded with Rifampicin for Wound Care.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Synthesis and Physicochemical Properties of Thermally Sensitive Polymeric Derivatives ofPolymers · 2024Article
- Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects.Gels (Basel, Switzerland) · 2023Review
- Article
- Synthetic Thermo-Responsive Terpolymers as Tunable Scaffolds for Cell Culture Applications.Polymers · 2022Article
- Review
- The inhibitory effect of curcumin loaded poly (vinyl caprolactam) nanohydrogel on insulin fibrillation.Process biochemistry (Barking, London, England) · 2022Article
- Article
- Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System.Pharmaceutics · 2021Review
- Thermoresponsive Chitosan-Grafted-Poly(Pharmaceutics · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Poly-N-Vinylcaprolactam (PNVCL) is a thermoresponsive polymer that exhibits lower critical solution temperature (LCST) between 25 and 50 °C. Due to its alleged biocompatibility, this polymer is becoming popular for biomedical and environmental applications. PNVCL with carboxyl terminations has been widely used for the preparation of thermoresponsive copolymers, micro- and nanogels for drug delivery and oncological therapies. However, the fabrication of such specific targeting devices needs standardized and reproducible preparation methods. This requires a deep understanding of how the miscibility behavior of the polymer is affected by its structural properties and the solution environment. In this work, PNVCL-COOH polymers were prepared via free radical polymerization (FRP) in order to exhibit LCST between 33 and 42 °C. The structural properties were investigated with NMR, FT-IR and conductimetric titration and the LCST was calculated via UV-VIS and DLS. The LCST is influenced by the molecular mass, as shown by both DLS and viscosimetric values. Finally, the behavior of the polymer was described as function of its concentration and in presence of different biologically relevant environments, such as aqueous buffers, NaCl solutions and human plasma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.