Evidence map›Paper›PMID 34451121›Full record

ArticlePolymers2021

Chitosan-Coated Poly(lactic acid) Nanofibres Loaded with Essential Oils for Wound Healing.

Giulia Milanesi, Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Elisa Mele

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Giulia MilanesiDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.
Barbara ViganiDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.
Silvia RossiDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-9511-3857
Giuseppina SandriDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-6766-9321
Elisa MeleMaterials Department, Loughborough University, Loughborough LE11 3TU, UK.ORCID 0000-0003-3574-7684
University of Pavia · ITLoughborough University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic skin wounds are characterised by a non-healing process that makes necessary the application of wound dressings on the damaged area to promote and facilitate the recovery of skin's physiological integrity. The aim of the present work is to develop a bioactive dressing that, once applied on the injured tissue, would exert antibacterial activity and promote adhesion and proliferation of fibroblasts. Nanofibres consisting of poly(lactic acid) (PLA) and essential oils (EOs) were electrospun and coated with a medium molecular weight chitosan (CS). Black pepper essential oil (BP-EO) or limonene (L), well-known for their antibacterial properties, were added to the PLA/acetone solution before electrospinning; phase separation phenomena occurred due to the poor solubility of the EOs in the PLA solution and led to fibres having surface nano-pores. The porous electrospun fibres were coated with CS to produce hydrophilic membranes that were easy to handle, biocompatible, and suited to promote cellular proliferation. The fibrous scaffolds were tested in terms of mechanical resistance, wettability, antibacterial activity, in-vitro cytotoxicity, and ability to promote fibroblasts' adhesion and proliferation. The results obtained proved that the CS coating improved the hydrophilicity of the fibrous mats, enhanced EO's antibacterial potential, and promoted cell adhesion and proliferation.

Indexed as

chitosanelectrospinningessential oils

Identifiers

PMID34451121
PMCPMC8398845
OpenAlexW3188961585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.