Evidence map›Paper›PMID 34450686›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2021

SARS-CoV-2 vaccination in solid-organ transplant recipients: What the clinician needs to know.

Maddalena Giannella, Lígia C Pierrotti, Ilkka Helanterä, Oriol Manuel

Open access · hybridAbstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Longevity of the humoral and cellular responses after SARS-CoV-2 booster vaccinations in immunocompromised patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Reduction in the risk of progression of solid organ transplant recipients infected by SARS-CoV-2 treated with monoclonal antibodies.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Review
  11. Article
  12. COVID‑19 vaccination in liver transplant recipients (Review).Experimental and therapeutic medicine · 2023
    Review
  13. Article
  14. Article
  15. Characteristics and outcomes of COVID-19 in heart transplantation recipients in the Netherlands.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Cohort profile:BMJ open · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Maddalena GiannellaInfectious Diseases Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Lígia C PierrottiDepartment of Infectious Diseases, University of São Paulo School of Medicine Hospital das Clínicas, São Paulo, Brazil.ORCID 0000-0002-0216-3028
Ilkka HelanteräTransplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Oriol ManuelInfectious Diseases Service and Transplantation Center, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0001-7607-0943
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Helsinki · FIUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to the COVID-19 pandemic, SARS-CoV-2 vaccines have been developed at an unparalleled speed, with 14 SARS-CoV-2 vaccines currently authorized. Solid-organ transplant (SOT) recipients are at risk for developing a higher rate of COVID-19-related complications and therefore they are at priority for immunization against SARS-CoV-2. Preliminary data suggest that although SARS-CoV-2 vaccines are safe in SOT recipients (with similar rate of adverse events than in the general population), the antibody responses are decreased in this population. Risk factors for poor vaccine immunogenicity include older age, shorter time from transplantation, use of mycophenolate and belatacept, and worse allograft function. SOT recipients should continue to be advised to maintain hand hygiene, use of facemasks, and social distancing after SARS-CoV-2 vaccine. Vaccination of household contacts should be also prioritized. Although highly encouraged for research purposes, systematic assessment in clinical practice of humoral and cellular immune responses after SARS-CoV-2 vaccination is controversial, since correlation between immunological findings and clinical protection from severe COVID-19, and cutoffs for protection are currently unknown in SOT recipients. Alternative immunization schemes, including a booster dose, higher doses, and modulation of immunosuppression during vaccination, need to be assessed in the context of well-designed clinical trials.

Indexed as

COVID-19Organ TransplantationAgedCOVID-19 VaccinesHumansPandemicsSARS-CoV-2Transplant RecipientsVaccinationCOVID-19 VaccinesimmunogenicitymRNA vaccineorgan transplantationpreventionsafetySARS-CoV-2

Identifiers

PMID34450686
PMCPMC8646251
OpenAlexW3195893659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.