ArticleThe Journal of antimicrobial chemotherapy2021
Limited phylogenetic overlap between fluoroquinolone-resistant Escherichia coli isolated on dairy farms and those causing bacteriuria in humans living in the same geographical region.
Article in The Journal of antimicrobial chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 21 citations in OpenAlex.
- Genomic epidemiology to investigate the origins and zoonotic implications of antibiotic-resistantOne health (Amsterdam, Netherlands) · 2026Article
- Genomic analyses of antibiotic-resistant Escherichia coli from extensive beef cattle and sheep farms identifies inter-species and farm-farm sharing as clonal dissemination pathways.The Journal of antimicrobial chemotherapy · 2026Article
- Fluoroquinolone resistance without fluoroquinolone use; the genie is truly out of the bottle.Frontiers in microbiology · 2026Review
- Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations.Antimicrobial agents and chemotherapy · 2025Review
- Changes in fecal microbiota after therapeutic exposure to amoxicillin-clavulanic acid in veal calves receiving multiple antibiotics.Microbiology spectrum · 2025Article
- Poultry-associated nitrofurantoin-resistant and pre-resistantOne health (Amsterdam, Netherlands) · 2025Article
- Three simple and cost-effective assays for AAC(6')-Ib-cr enzyme activity.Frontiers in microbiology · 2025Article
- Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway.BMC microbiology · 2024Article
- Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics.PLoS pathogens · 2024Article
- One health transmission of fluoroquinolone-resistantOne health (Amsterdam, Netherlands) · 2023Article
- Molecular ecology of highest priority critically important antibiotic resistant Escherichia coli from mammals housed at an urban zoo.The Journal of antimicrobial chemotherapy · 2023Article
- Article
- Understanding the role of veterinarians in antimicrobial stewardship on Canadian dairy farms: A mixed-methods study.PloS one · 2023Article
- Molecular ecology and risk factors for third-generation cephalosporin-resistant Escherichia coli carriage by dogs living in urban and nearby rural settings.The Journal of antimicrobial chemotherapy · 2022Article
- Evidence that faecal carriage of resistantOne health (Amsterdam, Netherlands) · 2022Article
- Baas Becking meets One Health.Nature microbiology · 2022Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOur primary aim was to test whether cattle-associated fluoroquinolone-resistant (FQ-R) Escherichia coli found on dairy farms are closely phylogenetically related to those causing bacteriuria in humans living in the same 50 × 50 km geographical region suggestive of farm-human sharing. Another aim was to identify risk factors for the presence of FQ-R E. coli on dairy farms.
methodsFQ-R E. coli were isolated during 2017-18 from 42 dairy farms and from community urine samples. Forty-two cattle and 489 human urinary isolates were subjected to WGS, allowing phylogenetic comparisons. Risk factors were identified using a Bayesian regularization approach.
resultsOf 489 FQ-R human isolates, 255 were also third-generation-cephalosporin-resistant, with strong genetic linkage between aac(6')Ib-cr and blaCTX-M-15. We identified possible farm-human sharing for pairs of ST744 and ST162 isolates, but minimal core genome SNP distances were larger between farm-human pairs of ST744 and ST162 isolates (71 and 63 SNPs, respectively) than between pairs of isolates from different farms (7 and 3 SNPs, respectively). Total farm fluoroquinolone use showed a positive association with the odds of isolating FQ-R E. coli, while total dry cow therapy use showed a negative association.
conclusionsThis work suggests that FQ-R E. coli found on dairy farms have a limited impact on community bacteriuria within the local human population. Reducing fluoroquinolone use may reduce the on-farm prevalence of FQ-R E. coli and this reduction may be greater when dry cow therapy is targeted to the ecology of resistant E. coli on the farm.
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