Evidence map›Paper›PMID 34450182›Full record

ReviewNeuroscience and biobehavioral reviews2021

Advancing a temporal framework for understanding the biology of nonsuicidal self- injury: An expert review.

Michael Kaess, Jill M Hooley, Bonnie Klimes-Dougan, Julian Koenig, Paul L Plener, Corinna Reichl, Kealagh Robinson, Christian Schmahl, Maurizio Sicorello, Mindy Westlund Schreiner and 1 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05563324 (Genetics of Self-injurious Behaviour), which is not on this map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05563324 completednot on this map

Genetics of Self-injurious Behaviour

TypeobservationalSponsorUniversity Medical Centre MariborRan2014 to 2018Enrolled234ConditionsSelf Injurious Behavior Without Suicidal Intent, Self-Injurious BehaviorArmsDNA extraction and genotyping of candidate genetic polymorphisms, self-assessment questionnaires
3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Serum Wnt Pathway Regulators in Adolescents with Suicidal Behavior Disorder and Nonsuicidal Self-injury Disorder: A Case-control Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael KaessUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: michael.kaess@upd.ch.
Jill M HooleyDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Bonnie Klimes-DouganDepartment of Psychology, College of Liberal Arts, University of Minnesota, Minneapolis, MN, USA.
Julian KoenigUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Cologne, Germany.
Paul L PlenerDepartment of Child and Adolescent Psychiatry, Medical University Vienna, Vienna, Austria; Department of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany.
Corinna ReichlUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Kealagh RobinsonSchool of Psychology, Victoria University of Wellington, Wellington, New Zealand.
Christian SchmahlDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
Maurizio SicorelloDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
Mindy Westlund SchreinerDepartment of Psychiatry, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Kathryn R CullenDepartment of Psychiatry and Behavioral Sciences, Medical School, University of Minnesota, Minneapolis, MN, USA.

Funding

A Longitudinal Study Examining Three RDoC Constructs in Adolescents with Non-Suicidal Self-InjuryR01MH107394 · NIMH · UNIVERSITY OF MINNESOTA · PI CULLEN, KATHRYN REGAN · 2016 to 2020
$3.1M
Developmental Trajectories of Brain Network Strength and Flexibility: Relationship to Risk, Onset and Course of Depression and Self-Harm in YouthR01MH122473 · NIMH · UNIVERSITY OF MINNESOTA · PI CULLEN, KATHRYN REGAN, FIECAS, MARK JOSEPH BARILAR · 2021 to 2024
$1.6M
Identifying Biological Signatures of N-acetylcysteine for Non-Suicidal Self-Injury in AdolescentsR61AT009995 · NCCIH · UNIVERSITY OF MINNESOTA · PI CULLEN, KATHRYN REGAN · 2018 to 2019
$611k
NCCIH NIH HHS R61 AT009995NIMH NIH HHS R01 MH107394NIMH NIH HHS R01 MH122473
6 · The paper itself

Abstract

Nonsuicidal self-injury (NSSI) is a serious clinical problem, particularly for adolescents and young adults. NSSI is a complex behavior that emerges through the intersecting effects of social, psychological, and biological mechanisms. Although the social and psychological contributions to risk for developing NSSI are relatively well understood and have guided the development of effective psychosocial treatments for self-injury, the biological mechanisms underlying NSSI have just begun to come to light. To evaluate and categorize the biological research conducted on the topic of NSSI, we propose a model that distinguishes between trait and state markers. According to this model, risk factors and mechanisms involved in NSSI can be distinguished into both trait and state factors. We review the existing evidence on distal biological traits (predictors) of NSSI, proximal biological traits (correlates) of NSSI, and biological states directly preceding or following NSSI. We conclude by providing recommendations for future research on the neurobiology of NSSI.

Indexed as

Self-Injurious BehaviorAdolescentHumansNeurobiologyPhenotypeRisk FactorsYoung AdultNeurobiologyNonsuicidal self- injuryStatesTemporal frameworkTraits

Identifiers

PMID34450182
PMCPMC8783544

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.