Evidence map›Paper›PMID 34450092›Full record

ReviewThe lancet. Diabetes & endocrinology2021

Adrenal myelolipomas.

Jan Calissendorff, Carl Christofer Juhlin, Anders Sundin, Irina Bancos, Henrik Falhammar

Open access · greenAbstract readReview
In one paragraph

Review in The lancet. Diabetes & endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Natural history of large adrenal tumors.Frontiers in endocrinology · 2026
    Article
  13. Article
  14. Petroclival extra-adrenal myelolipoma: illustrative case.Journal of neurosurgery. Case lessons · 2025
    Article
  15. Article
  16. Review
  17. Adrenal lipoma formation via PI(3,4,5)PProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jan CalissendorffDepartment of Endocrinology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Electronic address: jan.calissendorff@sll.se.
Carl Christofer JuhlinDepartment of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Anders SundinDepartment of Surgical Sciences, Radiology and Molecular Imaging, Uppsala University, Uppsala, Sweden.
Irina BancosDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Henrik FalhammarDepartment of Endocrinology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Mayo Clinic in Arizona · USUppsala University · SE

Funding

Skeletal Consequences of Mild Autonomous Cortisol SecretionK23DK121888 · NIDDK · MAYO CLINIC ROCHESTER · PI BANCOS, IRINA · 2019 to 2022
$630k
NIDDK NIH HHS K23 DK121888
6 · The paper itself

Abstract

Adrenal myelolipomas are benign, lipomatous tumours with elements of myeloid cells, most of which present as adrenal incidentalomas and comprise 3·3-6·5% of all adrenal masses. Adrenal myelolipomas are usually unilateral (in 95% of cases), variable in size, most often found during midlife, and affect both sexes almost equally. On imaging, adrenal myelolipomas show pathognomonic imaging features consistent with the presence of macroscopic fat. Large adrenal myelolipomas can cause symptoms of mass effect, and can occasionally be complicated by haemorrhage. In the event of a concomitant adrenal cortical adenoma or hyperplasia, adrenal hormone excess might be detected in patients with adrenal myelolipoma. Patients with congenital adrenal hyperplasia exhibit a higher prevalence of adrenal myelolipomas than other patient groups, and are at risk of developing large and bilateral lesions. This Review discusses the pathogenesis, clinical presentation, and management of adrenal myelolipomas.

Indexed as

Adrenal Gland NeoplasmsMyelolipomaAdrenal Hyperplasia, CongenitalAdrenocorticotropic HormoneAgedFemaleHumansMaleMiddle AgedMutationPrognosisProto-Oncogene ProteinsTomography, X-Ray ComputedAdrenocorticotropic HormoneMEN1 protein, humanProto-Oncogene Proteins

Identifiers

PMID34450092
PMCPMC8851410
OpenAlexW4205604322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.