ArticleMolecular cell2021
Mechanism of noncoding RNA-associated N
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Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review.Epigenetics · 2026Pooled it
- Epigenetic regulation of humoral immunity: molecular mechanisms, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- RNA mActa pharmacologica Sinica · 2026Review
- Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease.Nature reviews. Immunology · 2026Review
- The RNA-Binding Protein PARN Remodeled 3' UTR Structure Defines Poly(A)-Loading Sites to Mediate Immunoglobulin Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genetic and genomic approaches to explore roles for the conserved 3'-5' exoribonuclease EXOSC10 in normal and malignant cells.RNA (New York, N.Y.) · 2026Review
- Diverse roles of YTHDC1 in chromatin and blood cancers.Frontiers in genetics · 2026Review
- Phase separation as an emerging regulatory framework in antibody class switching and genome stability.Frontiers in immunology · 2026Review
- mNature structural & molecular biology · 2025Article
- Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells.Cell reports · 2025Article
- The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells.Exploration (Beijing, China) · 2025Article
- The Role of MClinical reviews in allergy & immunology · 2025Review
- Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus.Nature communications · 2025Article
- B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2024Article
- METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus.BMC medicine · 2024Article
- NMolecular medicine (Cambridge, Mass.) · 2024Review
- Article
- BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL.Nucleic acids research · 2024Article
- RNA m6A modification, signals for degradation or stabilisation?Biochemical Society transactions · 2024Review
- RNA processing mechanisms contribute to genome organization and stability in B cells.Oncogene · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 3 countries.
Lekha NairDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Wanwei ZhangDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Brice LaffleurDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Mukesh K JhaDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Junghyun LimDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Heather LeeDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Lijing WuDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Nehemiah S AlvarezDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Zhi-Ping LiuDepartment of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan 250061, Shandong, China.
Emilia L MunteanuHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Theresa SwayneHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Lei DingDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Gerson RothschildDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: ger2@cumc.columbia.edu.
Uttiya BasuDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: ub2121@cumc.columbia.edu.
Columbia University · USColumbia University Irving Medical Center · USShandong University · CNUniversity of Kansas Medical Center · USWeizmann Institute of Science · IL
Funding
Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic HypermutationR01AI099195 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2012 to 2026
$9.8MLong noncoding RNA expressing genomic element that control antibody diversification and chromosomal integrity in B cellsR01AI134988 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2018 to 2026
$4.7MThe role of N6-methyladenosine RNA modification in programmed and aberrant DNA mutagenesis in B cellsR01AI143897 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2020 to 2026
$3.4MUnderstanding the role of stellate cells in the liver hematopoietic stem cell nicheR01HL153487 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2020 to 2024
$2.8MUnderstanding and targeting bone marrow microenvironment in myelofibrosisR01HL155868 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2021 to 2024
$2.3MNHLBI NIH HHS R01 HL153487NHLBI NIH HHS R01 HL155868NIAID NIH HHS R01 AI099195NIAID NIH HHS R01 AI134988NIAID NIH HHS R01 AI143897
Abstract
Immunoglobulin heavy chain (IgH) locus-associated G-rich long noncoding RNA (SμGLT) is important for physiological and pathological B cell DNA recombination. We demonstrate that the METTL3 enzyme-catalyzed N
Indexed as
Recombination, GeneticRNA 3' End ProcessingAdenosineAICDA (Activation-Induced Cytidine Deaminase)AnimalsB-LymphocytesCytidine DeaminaseExosome Multienzyme Ribonuclease ComplexFemaleGenomic InstabilityHEK293 CellsHumansImmunoglobulin Class SwitchingImmunoglobulin Heavy ChainsMaleMembrane ProteinsAdenosineAICDA (Activation-Induced Cytidine Deaminase)Cytidine DeaminaseExosome Multienzyme Ribonuclease ComplexGt(ROSA)26Sor non-coding RNA, mouseImmunoglobulin Heavy ChainsMembrane ProteinsMethyltransferasesMettl3 protein, mouseMPP6 protein, mouseN-methyladenosineRNA, Long NoncodingRNA, UntranslatedAIDantibodyB cellclass switch recombinationdouble-strand breaklncRNAm6AMETTL3RNA:DNA hybridRNA exosome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.