Evidence map›Paper›PMID 34450041›Full record

ArticleStem cell reports2021

NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia.

Daisuke Araki, Jian Fei Fu, Heather Huntsman, Stefan Cordes, Fayaz Seifuddin, Luigi J Alvarado, Patali S Cheruku, Ayla Cash, Javier Traba, Yuesheng Li and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Daisuke ArakiCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
Jian Fei FuCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
Heather HuntsmanCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
Stefan CordesTranslational Stem Cell Biology Branch, NHLBI, NIH, Bethesda, MD 20892, USA.
Fayaz SeifuddinBioinformatics and Computational Biology Laboratory, NHLBI, NIH, Bethesda, MD 20892, USA.
Luigi J AlvaradoCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
Patali S CherukuCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
Ayla CashCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
Javier TrabaCardiovascular Branch, NHLBI, NIH, Bethesda, MD 20892, USA.
Yuesheng LiDNA Sequencing and Genomics Core Facility, NHLBI, NIH, Bethesda, MD 20892, USA.
Mehdi PiroozniaBioinformatics and Computational Biology Laboratory, NHLBI, NIH, Bethesda, MD 20892, USA.
Richard H SmithCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA.
Andre LarochelleCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: larochea@nhlbi.nih.gov.
National Institutes of Health · USNational Heart Lung and Blood Institute · US

Funding

Regenerative Therapies for Inherited Blood Disorders-Gene therapyZIAHL006172 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LAROCHELLE, ANDRE · 2013 to 2025
$13.0M
Regenerative Therapies for Inherited Blood Disorders-iPSC differentiationZIAHL006217 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LAROCHELLE, ANDRE · 2016 to 2025
$8.5M
Bioinformatics CoreZICHL006228 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI PIROOZNIA, MEHDI · 2017 to 2021
$6.6M
Regenerative Therapies for Inherited Blood Disorders-HSC expansionZIAHL006218 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LAROCHELLE, ANDRE · 2016 to 2022
$3.2M
Intramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA HL006218
6 · The paper itself

Abstract

Activation of NOTCH signaling in human hematopoietic stem/progenitor cells (HSPCs) by treatment with an engineered Delta-like ligand (DELTA1

Indexed as

Cell HypoxiaAntigens, CD34BiomarkersCell Culture TechniquesCell DifferentiationCell ProliferationComputational BiologyHematopoietic Stem CellsHumansMolecular Sequence AnnotationReceptors, NotchSignal TransductionTranscriptomeAntigens, CD34BiomarkersReceptors, Notchendoplasmic reticulum stressexpansiongene therapyhematopoietic stem cellhypoxiaNotchpathwayssignalingtransplantation

Identifiers

PMID34450041
PMCPMC8452537
OpenAlexW3195729143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.