Evidence map›Paper›PMID 34450026›Full record

ArticleNeuron2021

Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice.

Anna K Gillespie, Daniela A Astudillo Maya, Eric L Denovellis, Daniel F Liu, David B Kastner, Michael E Coulter, Demetris K Roumis, Uri T Eden, Loren M Frank

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cognitive maps as a medium for thought.Trends in cognitive sciences · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  11. Planning in the Brain: It's Not What You Think It Is.Annual review of neuroscience · 2026
    Review
  12. Article
  13. Skill Memory Expansion Shapes Micro-Scale Dynamics of Skill Learning.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026
    Article
  18. Long-Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  19. Review
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Anna K GillespieDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: anna.gillespie@ucsf.edu.
Daniela A Astudillo MayaDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Eric L DenovellisDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Daniel F LiuDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
David B KastnerDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Michael E CoulterDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Demetris K RoumisDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Uri T EdenDepartment of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
Loren M FrankDepartments of Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: loren@phy.ucsf.edu.

Funding

Real-time manipulations to understand and improve memory processesK99AG068425 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GILLESPIE, ANNA KATHLEEN · 2020 to 2022
$323k
Howard Hughes Medical InstituteNIA NIH HHS K99 AG068425
6 · The paper itself

Abstract

Executing memory-guided behavior requires storage of information about experience and later recall of that information to inform choices. Awake hippocampal replay, when hippocampal neural ensembles briefly reactivate a representation related to prior experience, has been proposed to critically contribute to these memory-related processes. However, it remains unclear whether awake replay contributes to memory function by promoting the storage of past experiences, facilitating planning based on evaluation of those experiences, or both. We designed a dynamic spatial task that promotes replay before a memory-based choice and assessed how the content of replay related to past and future behavior. We found that replay content was decoupled from subsequent choice and instead was enriched for representations of previously rewarded locations and places that had not been visited recently, indicating a role in memory storage rather than in directly guiding subsequent behavior.

Indexed as

AlgorithmsAnimalsChoice BehaviorConditioning, OperantElectrodes, ImplantedGoalsHippocampusLinear ModelsMaleMaze LearningMemoryRatsRats, Long-EvansSpace Perceptionconsolidationdecodinghippocampuslearningmemorynavigationplanningreplaysharp wave ripples

Identifiers

PMID34450026
PMCPMC8497431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.