ArticleThe Journal of cell biology2021
Mechanical competition alters the cellular interpretation of an endogenous genetic program.
Article in The Journal of cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Ectoderm tensile stress controls mesoderm internalization during embryo gastrulation.Nature communications · 2026Article
- Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.Nature communications · 2025Article
- Studying gastrulation by invagination: The bending of a cell sheet by mechanical cell properties using 3D deformable cell based simulations.PLoS computational biology · 2025Article
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila.Current biology : CB · 2024Article
- Polarised cell intercalation during Drosophila axis extension is robust to an orthogonal pull by the invaginating mesoderm.PLoS biology · 2024Article
- Mechanical control of neural plate folding by apical domain alteration.Nature communications · 2023Article
- The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis.Developmental cell · 2023Review
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability inbioRxiv : the preprint server for biology · 2023Article
- Actomyosin pulsing rescues embryonic tissue folding from disruption by myosin fluctuations.Research square · 2023Article
- Recoil Measurements inBio-protocol · 2023Article
- Sculpting with stiffness: rigidity as a regulator of morphogenesis.Biochemical Society transactions · 2023Review
- High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development.Nature methods · 2023Article
- Cellular segregation in cocultures is driven by differential adhesion and contractility on distinct timescales.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure.Development (Cambridge, England) · 2022Article
- Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation.Nature communications · 2022Article
- The Lateral Epidermis Actively Counteracts Pulling by the Amnioserosa During Dorsal Closure.Frontiers in cell and developmental biology · 2022Article
- Generation and timing of graded responses to morphogen gradients.Development (Cambridge, England) · 2021Article
- Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature.Development (Cambridge, England) · 2021Article
- Programmed and self-organized flow of information during morphogenesis.Nature reviews. Molecular cell biology · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intrinsic genetic program of a cell is not sufficient to explain all of the cell's activities. External mechanical stimuli are increasingly recognized as determinants of cell behavior. In the epithelial folding event that constitutes the beginning of gastrulation in Drosophila, the genetic program of the future mesoderm leads to the establishment of a contractile actomyosin network that triggers apical constriction of cells and thereby tissue folding. However, some cells do not constrict but instead stretch, even though they share the same genetic program as their constricting neighbors. We show here that tissue-wide interactions force these cells to expand even when an otherwise sufficient amount of apical, active actomyosin is present. Models based on contractile forces and linear stress-strain responses do not reproduce experimental observations, but simulations in which cells behave as ductile materials with nonlinear mechanical properties do. Our models show that this behavior is a general emergent property of actomyosin networks in a supracellular context, in accordance with our experimental observations of actin reorganization within stretching cells.
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